{"id":"W1886119278","doi":"10.1089/scd.2014.0023","title":"Activation of Neural Cell Fate Programs Toward Direct Conversion of Adult Human Fibroblasts into Tri-Potent Neural Progenitors Using <i>OCT-4</i>","year":2014,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Biology; Neural stem cell; Reprogramming; Neural cell; Cell fate determination; Progenitor cell; Neurosphere; Neural development; Cell biology; Transcription factor; Neuroscience; Cellular differentiation; Stem cell; Cell; Adult stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365384,0.0002748472,0.00009102676,0.0001943397,0.0001161335,0.0002495516,0.0001189519,0.0001233356,0.0008134085],"category_scores_gemma":[0.00009757053,0.0001073623,0.0002065684,0.00009632205,0.0001572181,0.0001175512,0.0001652289,0.0002884051,0.000324555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518233,"about_ca_system_score_gemma":0.000209299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005459376,"about_ca_topic_score_gemma":0.0009205496,"domain_scores_codex":[0.9998832,0.00001653956,0.00001364789,0.00002132944,0.00004303635,0.00002221194],"domain_scores_gemma":[0.999934,0.00001702966,0.00001464008,0.0000127161,0.00001004768,0.00001167536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002561631,0.00001405349,0.0001617636,0.00001791594,0.000002010563,0.00004121957,0.00001310287,0.00006465186,0.9977732,0.0001522967,0.00001934991,0.001714812],"study_design_scores_gemma":[0.000002530088,0.00004409744,0.0007273536,0.000002089122,0.000003208823,0.0001138314,0.000007578421,0.0003151681,0.9975885,0.00002826559,0.001166004,0.000001327846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631844,0.0008763266,0.02662588,0.0001010296,0.00004131982,0.0001507747,0.0005793033,0.0002088625,0.008232084],"genre_scores_gemma":[0.9788454,0.0009897202,0.01544191,0.00005808637,0.000008022171,0.00008106093,0.0006811758,0.00003159002,0.003863061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008134085,"threshold_uncertainty_score":0.002721071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01947073871536908,"score_gpt":0.24571850999549,"score_spread":0.2262477712801209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}