{"id":"W1886211687","doi":"10.1002/cpt.284","title":"Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma","year":2015,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Omalizumab; Asthma; Immunology; Medicine; Monoclonal antibody; Immunoglobulin E; Cytokine; Mepolizumab; Antibody; Allergy; Eosinophil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001279585,0.001067985,0.004142578,0.0004882546,0.000204318,0.00003740925,0.0006389329,0.001135347,0.000452359],"category_scores_gemma":[0.00007714221,0.0007740689,0.00117265,0.001333044,0.0008672107,0.00008060494,0.000352482,0.002145378,0.001042113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002216481,"about_ca_system_score_gemma":0.002993767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001562655,"about_ca_topic_score_gemma":4.501826e-7,"domain_scores_codex":[0.9937702,0.001418059,0.002132461,0.001221613,0.0005641246,0.0008935807],"domain_scores_gemma":[0.9962614,0.000860308,0.0007992154,0.0006454592,0.0005709119,0.0008627143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005087866,0.001190048,0.0003005243,0.002013425,0.004472799,0.0002254311,0.000169604,0.000003063029,0.00001341284,0.0000450597,0.01300766,0.9780502],"study_design_scores_gemma":[0.001556578,0.001610403,0.0002102261,0.001120724,0.006691906,0.00009763012,0.0001219942,0.00003922196,0.00001585032,0.00007866042,0.987726,0.000730824],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000833737,0.9900343,0.00008810425,0.002496658,0.002537099,0.002632034,0.00009918737,0.0002376157,0.001041195],"genre_scores_gemma":[0.000185124,0.9427136,0.0005021982,0.05190524,0.002829103,0.0002757021,0.000258551,0.0002235289,0.001106919],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9773194,"threshold_uncertainty_score":0.9997357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4073594702037661,"score_gpt":0.5071271919195822,"score_spread":0.0997677217158161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}