{"id":"W1887821162","doi":"10.1016/j.jalz.2015.05.003","title":"The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans","year":2015,"lang":"en","type":"review","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Science Foundation, United Arab Emirates; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; National Institutes of Health; Ministry of Science, ICT and Future Planning; National Research Foundation; Northern California Institute for Research and Education; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; University of California, San Diego; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Biomarker; Alzheimer's Disease Neuroimaging Initiative; Biobank; Neuroimaging; Disease; Medicine; Amyloid beta; Oncology; Alzheimer's disease; Psychology; Neuroscience; Internal medicine; Bioinformatics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004807945,0.001274978,0.00318663,0.008483707,0.0004100568,0.002109662,0.00186179,0.001669167,0.004254369],"category_scores_gemma":[0.00723586,0.0007190066,0.002111979,0.00723624,0.0005696043,0.002822256,0.001232172,0.001925638,0.001388905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001844157,"about_ca_system_score_gemma":0.006561974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00353009,"about_ca_topic_score_gemma":0.005941965,"domain_scores_codex":[0.9989059,0.0002445848,0.0003169603,0.0001434921,0.0003231677,0.00006587872],"domain_scores_gemma":[0.9959247,0.002011771,0.000796522,0.00007267587,0.001020588,0.0001737408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001498415,0.00006470003,0.0003022914,0.1533249,0.0003826796,0.0001000859,0.0001346496,0.0002730336,0.0003885376,0.003406386,0.0298751,0.8115978],"study_design_scores_gemma":[0.00007297542,0.0002060445,0.001928312,0.1553262,0.001709196,0.000706003,0.0001825826,0.0001551809,0.0002695289,0.002815006,0.8365765,0.00005249324],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004301968,0.998949,0.00007619493,0.0004708373,0.0001298949,0.00002555445,0.00004476831,0.000005430742,0.0002553351],"genre_scores_gemma":[0.0003133912,0.9987676,0.0003529873,0.0002864543,0.00008618383,0.00003274793,0.00005773084,0.000001637257,0.0001012153],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008483707,"threshold_uncertainty_score":0.02542716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1427812303360423,"score_gpt":0.4158644802061593,"score_spread":0.273083249870117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}