{"id":"W1888320884","doi":"10.1055/s-0037-1613063","title":"Aberrant Splicing and Premature Termination of Transcription of the FVIII Gene as a Cause of Severe Canine Hemophilia A: Similarities with the Intron 22 Inversion Mutation in Human Hemophilia","year":2002,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Bayer Canada; Canadian Hemophilia Society; Canadian Blood Services; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Intron; RNA splicing; Gene; Medicine; Genetics; Mutation; Transcription (linguistics); Biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133435,0.0002228836,0.0002258186,0.0003930332,0.0001633148,0.0001946019,0.0001157708,0.0003426194,0.00083696],"category_scores_gemma":[0.0003337805,0.0000964936,0.0001453121,0.0002474793,0.0004610124,0.00009166272,0.0001366019,0.000280312,0.0002489682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001609296,"about_ca_system_score_gemma":0.0001356268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005946868,"about_ca_topic_score_gemma":0.0008662171,"domain_scores_codex":[0.9998683,0.00002218284,0.00001220565,0.00002708142,0.0000490725,0.00002114668],"domain_scores_gemma":[0.9997942,0.00005241051,0.00007846612,0.00001890509,0.00001788504,0.00003826541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005331193,0.0001298498,0.0421996,0.0001182334,0.00003900359,0.06533479,0.0007039298,0.0005309449,0.876967,0.0008617343,0.0003909689,0.01219072],"study_design_scores_gemma":[0.0002002585,0.001214669,0.390848,0.00003909739,0.000169821,0.3729998,0.0003903039,0.00455609,0.217564,0.001401245,0.01056869,0.00004807543],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998823,0.0002083688,0.0005520557,0.00003330402,0.000006096595,0.000004664896,0.00002259454,0.0000128131,0.000337194],"genre_scores_gemma":[0.9989573,0.0001670913,0.0004746046,0.00003060316,0.00001373669,0.000003000098,0.00007877284,0.000008343133,0.0002666397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00083696,"threshold_uncertainty_score":0.002799928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04450216459636933,"score_gpt":0.2956124277086834,"score_spread":0.2511102631123141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}