{"id":"W1888592485","doi":"10.1002/emmm.201000084","title":"Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease","year":2010,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging; Hereditary Disease Foundation; National Institutes of Health; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; CHDI Foundation","keywords":"Tissue transglutaminase; Huntington's disease; Immune dysregulation; Disease; HEK 293 cells; Cell biology; Chemistry; Neuroscience; Biology; Medicine; Genetics; Enzyme; Gene; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150513,0.0004467099,0.0004213433,0.0002192091,0.000112411,0.0002399974,0.0002090688,0.0002121763,0.0008070359],"category_scores_gemma":[0.00007423995,0.0001398711,0.0001875088,0.0001150684,0.0002654846,0.0001730936,0.000152804,0.0005526617,0.0001645271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000268874,"about_ca_system_score_gemma":0.0001781512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005356008,"about_ca_topic_score_gemma":0.002066898,"domain_scores_codex":[0.9998981,0.00001712791,0.00001098772,0.00003003435,0.0000202574,0.0000234834],"domain_scores_gemma":[0.9999408,0.000005958616,0.00002231446,0.000007549369,0.000006524119,0.0000169278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002254245,0.00006248052,0.00009727767,0.00002669343,0.00001085478,0.00001698234,0.000009823843,0.00004814294,0.9981571,0.00004302036,0.00003040252,0.00127179],"study_design_scores_gemma":[0.00005844333,0.001335238,0.002860147,0.00000532377,0.00004037036,0.0001020291,0.00002865714,0.0005106125,0.9933303,0.00005233179,0.001671773,0.000004703505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995862,0.001290834,0.001701021,0.0001014125,0.00003488074,0.00002617003,0.0001995268,0.0001133207,0.0006707573],"genre_scores_gemma":[0.9942111,0.001118279,0.001640382,0.0000787697,0.00001507377,0.00004636027,0.0004631041,0.00002680106,0.002400208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008070359,"threshold_uncertainty_score":0.002699852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792124342516864,"score_gpt":0.2541267843118552,"score_spread":0.2362055408866865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}