{"id":"W1888592485","doi":"10.1002/emmm.201000084","title":"Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease","year":2010,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging; Hereditary Disease Foundation; National Institutes of Health; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; CHDI Foundation","keywords":"Tissue transglutaminase; Huntington's disease; Immune dysregulation; Disease; HEK 293 cells; Cell biology; Chemistry; Neuroscience; Biology; Medicine; Genetics; Enzyme; Gene; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521075,0.0001461799,0.0002288919,0.0002345127,0.00002532816,0.000003381177,0.0001127491,0.00004454473,0.0001154668],"category_scores_gemma":[0.0004208823,0.0001373198,0.00007628831,0.0003446488,0.0003992461,0.0001122007,0.00001153039,0.0001330087,0.000001068708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007416894,"about_ca_system_score_gemma":0.00006298838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000211435,"about_ca_topic_score_gemma":0.00001201719,"domain_scores_codex":[0.998426,0.0001396423,0.0004319963,0.0003338352,0.0005053409,0.0001632528],"domain_scores_gemma":[0.9993343,0.0000750994,0.000127521,0.0002435989,0.0000880207,0.0001314269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007335061,0.0001818072,0.0004812748,0.00008541343,0.000001980563,0.00001190257,0.0003484048,0.003282806,0.9818737,0.01328101,0.000005514888,0.000372865],"study_design_scores_gemma":[0.001083157,0.00009504988,0.02824837,0.0001141253,0.00003436773,0.000001114985,0.00003217818,0.004773611,0.9563636,0.009147056,0.000007898041,0.00009942622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940578,0.00008230201,0.004118572,0.0007726873,0.0001374483,0.0003075062,0.00004659854,0.00001641711,0.0004606784],"genre_scores_gemma":[0.99932,0.00001346072,0.0002411133,0.0002989942,0.00003533372,0.00002154563,0.0000340216,0.00001922543,0.00001628792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02776709,"threshold_uncertainty_score":0.5599738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792124342516864,"score_gpt":0.2541267843118552,"score_spread":0.2362055408866865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}