{"id":"W1889047264","doi":"10.1111/mmi.12065","title":"A defect in <scp>ATP</scp>‐citrate lyase links acetyl‐<scp>CoA</scp> production, virulence factor elaboration and virulence in <i><scp>C</scp>ryptococcus neoformans</i>","year":2012,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Virulence; Cryptococcus neoformans; ATP citrate lyase; Mutant; Virulence factor; Microbiology; Antifungal drug; Intracellular; Cryptococcosis; Pathogen; Gene; Biochemistry; Candida albicans; Enzyme; Citrate synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007022959,0.0005751624,0.0007947729,0.000548966,0.0002329833,0.00005211226,0.0001821894,0.000664426,0.000006933591],"category_scores_gemma":[0.00260796,0.0005286679,0.0001729679,0.001074095,0.0003990982,0.0003940728,0.0002004049,0.001167062,0.0001314037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002028512,"about_ca_system_score_gemma":0.0001460877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001449571,"about_ca_topic_score_gemma":0.0001997311,"domain_scores_codex":[0.9966204,0.0003658513,0.000775677,0.0008848561,0.0001439988,0.001209285],"domain_scores_gemma":[0.998129,0.0005144026,0.0002749755,0.0005538853,0.0002875347,0.0002401655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001246618,0.0003854487,0.0664238,0.00015444,0.0001159391,0.00006064418,0.003454382,0.00007177488,0.9246595,0.0001197448,0.004181051,0.0003608385],"study_design_scores_gemma":[0.003487761,0.001391823,0.07603379,0.0004154608,0.0002255605,0.0008689075,0.003112116,0.0001226588,0.735035,0.0001172943,0.1789589,0.0002306926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849134,0.01076405,0.0007750071,0.0003496805,0.000758418,0.001479773,0.00008925439,0.0001311671,0.0007392194],"genre_scores_gemma":[0.9940279,0.002080462,0.0006719559,0.002068248,0.000213541,0.0002990035,0.0001485177,0.0000673315,0.0004230261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1896245,"threshold_uncertainty_score":0.9997165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086814706291033,"score_gpt":0.248229250492404,"score_spread":0.2373611034294937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}