{"id":"W1889047264","doi":"10.1111/mmi.12065","title":"A defect in <scp>ATP</scp>‐citrate lyase links acetyl‐<scp>CoA</scp> production, virulence factor elaboration and virulence in <i><scp>C</scp>ryptococcus neoformans</i>","year":2012,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Virulence; Cryptococcus neoformans; ATP citrate lyase; Mutant; Virulence factor; Microbiology; Antifungal drug; Intracellular; Cryptococcosis; Pathogen; Gene; Biochemistry; Candida albicans; Enzyme; Citrate synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031659,0.0004279214,0.0001690653,0.0002500933,0.0001329908,0.0002498804,0.0002264162,0.000295835,0.0006918648],"category_scores_gemma":[0.0001999139,0.0001340073,0.0002234417,0.0001923448,0.0003187605,0.00009234485,0.0001890093,0.0004086065,0.0002631811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005209511,"about_ca_system_score_gemma":0.0003730971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005220646,"about_ca_topic_score_gemma":0.003632431,"domain_scores_codex":[0.9998678,0.00001848599,0.00001528456,0.00002797023,0.00004313841,0.00002736522],"domain_scores_gemma":[0.9998326,0.0000296274,0.00005906318,0.00001461042,0.00001768337,0.00004636953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006542204,0.00001848244,0.0004142094,0.00001438522,0.000004102314,0.000135412,0.000008500954,0.0000844224,0.9986505,0.00003398858,0.00001720356,0.0005534291],"study_design_scores_gemma":[0.00001013246,0.0001406288,0.01632328,0.000008526122,0.00001309081,0.001111215,0.00004025824,0.0016862,0.979826,0.00004757244,0.0007861122,0.000006914805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972429,0.0001608404,0.001661281,0.00006689485,0.00000939865,0.00001615179,0.0003924658,0.00004895756,0.0004010764],"genre_scores_gemma":[0.9976003,0.0001051366,0.001178832,0.0000312673,0.000002579484,0.000009924733,0.0004206419,0.00001597881,0.0006352493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005220646,"threshold_uncertainty_score":0.01038051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086814706291033,"score_gpt":0.248229250492404,"score_spread":0.2373611034294937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}