{"id":"W1889164960","doi":"10.1371/journal.pbio.1002282","title":"Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress","year":2015,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Schulich School of Medicine and Dentistry; Georgetown University; Dartmouth College; National Alliance for Research on Schizophrenia and Depression; Institute of Biomedical Sciences, Academia Sinica; National Institutes of Health; Yale University; National Center for PTSD, U.S. Department of Veterans Affairs; Uniformed Services University of the Health Sciences; Academia Sinica; U.S. Department of Veterans Affairs","keywords":"Prefrontal cortex; Learned helplessness; SGK1; Neuroscience; Amygdala; Traumatic stress; Dendritic spine; Neuroplasticity; Biology; Anhedonia; Phenotype; Rodent model; Pathophysiology; Major depressive disorder; Psychology; Glucocorticoid; Endocrinology; Cognition; Clinical psychology; Hippocampal formation; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000597997,0.0003019903,0.0002198083,0.0002109199,0.0001540574,0.0001974036,0.0001144841,0.0001586544,0.0006973881],"category_scores_gemma":[0.00008583123,0.00009697604,0.0002077563,0.0001088911,0.0002844797,0.000103941,0.0001770486,0.0004354242,0.000148367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002824999,"about_ca_system_score_gemma":0.0001649198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000727438,"about_ca_topic_score_gemma":0.001236157,"domain_scores_codex":[0.9999555,0.000004645576,0.000003536383,0.0000138203,0.000007552325,0.0000148609],"domain_scores_gemma":[0.9999233,0.000002996723,0.00004209254,0.00000554882,0.000006060489,0.00001999221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006160972,0.00003925771,0.004917605,0.00009128195,0.0000318724,0.0001780878,0.0000435382,0.00007208399,0.9899705,0.00007749393,0.0001225852,0.003839634],"study_design_scores_gemma":[0.00004402855,0.0009250939,0.5651121,0.000038248,0.0001695571,0.002061012,0.000344956,0.001185216,0.4269213,0.0004535187,0.002723545,0.00002140567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970752,0.001691739,0.0005357157,0.0001139441,0.00001643308,0.000005301446,0.0002180239,0.00003172905,0.0003120429],"genre_scores_gemma":[0.9975776,0.001375164,0.0002609853,0.00003515914,0.000006013528,0.000006125202,0.0002497346,0.000005640552,0.0004834876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000727438,"threshold_uncertainty_score":0.002332926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1046395741998474,"score_gpt":0.3189918119261779,"score_spread":0.2143522377263305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}