{"id":"W1889825709","doi":"10.4049/jimmunol.179.10.7110","title":"Induction of IRAK-M Is Associated with Lipopolysaccharide Tolerance in a Human Endotoxemia Model","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Lipopolysaccharide; Monocyte; In vivo; Whole blood; Cytokine; Tumor necrosis factor alpha; In vitro; Pharmacology; Ex vivo; Internal medicine; Endocrinology; Biology; Medicine; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001786015,0.0001236319,0.0003685553,0.00031802,0.0001008112,0.000003110354,0.0003000121,0.0002537887,0.00006877665],"category_scores_gemma":[0.0001371588,0.00008108868,0.00006999238,0.0001866791,0.0002811035,0.0001670787,0.00003671016,0.0006622884,0.000008299533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009429389,"about_ca_system_score_gemma":0.0001065284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009336414,"about_ca_topic_score_gemma":0.00005199514,"domain_scores_codex":[0.9985291,0.0003195037,0.0007500306,0.00007429991,0.00005574057,0.0002713611],"domain_scores_gemma":[0.9984524,0.0002209275,0.0008934278,0.0002035711,0.0002223949,0.000007304986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002200703,0.00009962683,0.0005019075,0.000003265485,0.0002541794,0.000006635068,0.002638447,0.0003887919,0.9919022,0.0003995039,0.0000916767,0.001513016],"study_design_scores_gemma":[0.002342919,0.0006790059,0.01273251,0.0001229344,0.00005927345,0.0004663938,0.0007496896,0.00002699103,0.9821885,0.0004028748,0.0001387789,0.00009009791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963971,0.001909826,0.0008780154,0.0002396634,0.0002108469,0.0001102528,0.000001248595,0.000007742439,0.0002452626],"genre_scores_gemma":[0.9992723,0.0001766593,0.00003494937,0.00007871365,0.00001719002,0.000001280837,0.00000372292,0.00001078369,0.0004044021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0122306,"threshold_uncertainty_score":0.33067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339506933328175,"score_gpt":0.2469052721186897,"score_spread":0.2335102027854079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}