{"id":"W1890443126","doi":"10.1046/j.1365-2958.2003.03797.x","title":"Invasive M1T1 group A <i>Streptococcus</i> undergoes a phase‐shift <i>in vivo</i> to prevent proteolytic degradation of multiple virulence factors by SpeB","year":2003,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases","keywords":"Virulence; Streptococcus pyogenes; Biology; Proteome; Streptococcus; Proteases; Microbiology; Group A; Cysteine protease; Molecular biology; Genetics; Biochemistry; Gene; Bacteria; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009106444,0.0002548191,0.000415246,0.000176031,0.00004144721,0.000007964936,0.00008317329,0.0001573382,0.0001509736],"category_scores_gemma":[0.0002181426,0.0002172602,0.0001404822,0.0003517563,0.00009363656,0.00004453257,0.00003602569,0.0001364002,0.00002300028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001488398,"about_ca_system_score_gemma":0.00009031487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002540684,"about_ca_topic_score_gemma":0.0002320689,"domain_scores_codex":[0.9985575,0.0001635974,0.0004073767,0.0004659116,0.00006466209,0.0003409519],"domain_scores_gemma":[0.9992556,0.0001057059,0.0001378361,0.000325611,0.00005260596,0.000122618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006833381,0.001401243,0.0608029,0.00004694777,0.0001084769,0.0000314522,0.00008867863,0.000009406986,0.9369075,0.0001289542,0.0002911325,0.0001149938],"study_design_scores_gemma":[0.003253662,0.00126689,0.0009464014,0.0001307049,0.00007446571,0.00003372826,0.00006567002,0.000002812107,0.9905809,0.00007876148,0.003388328,0.0001776565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933776,0.0001998263,0.003288838,0.00009051423,0.0000778702,0.002524065,0.0001433421,0.00002902158,0.0002689064],"genre_scores_gemma":[0.9983395,0.00001603926,0.0006681739,0.0003067986,0.000005315173,0.000312194,0.000189953,0.00002483681,0.0001371388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05985649,"threshold_uncertainty_score":0.8859615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168324967652032,"score_gpt":0.2658665999164253,"score_spread":0.254183350239905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}