{"id":"W1890443126","doi":"10.1046/j.1365-2958.2003.03797.x","title":"Invasive M1T1 group A <i>Streptococcus</i> undergoes a phase‐shift <i>in vivo</i> to prevent proteolytic degradation of multiple virulence factors by SpeB","year":2003,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases","keywords":"Virulence; Streptococcus pyogenes; Biology; Proteome; Streptococcus; Proteases; Microbiology; Group A; Cysteine protease; Molecular biology; Genetics; Biochemistry; Gene; Bacteria; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302417,0.0003674592,0.0002309762,0.0001304145,0.0001215665,0.0002671194,0.0001929635,0.0002332515,0.0006610051],"category_scores_gemma":[0.000166056,0.0001540996,0.0002292967,0.00009974143,0.0001853491,0.000140893,0.0002118678,0.000484869,0.0003006026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002714999,"about_ca_system_score_gemma":0.0001892296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007051475,"about_ca_topic_score_gemma":0.0007872247,"domain_scores_codex":[0.9998664,0.00001906659,0.000009534154,0.0000275977,0.00003848113,0.00003893414],"domain_scores_gemma":[0.9998897,0.00001345254,0.00004372366,0.00001578935,0.00001147148,0.00002577035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005790904,0.00001807736,0.0001746813,0.000007912575,0.000001416455,0.00001406039,0.000006236505,0.00001571006,0.9993895,0.00002077087,0.00001215692,0.000281486],"study_design_scores_gemma":[0.00001238698,0.0005711935,0.01262966,0.000006295184,0.000009695594,0.0003346033,0.00003056896,0.0006665252,0.984558,0.00002863421,0.001147751,0.000004595042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984888,0.0002008489,0.0007678904,0.00004142243,0.000007867709,0.00001525256,0.0001143233,0.00002355017,0.0003401221],"genre_scores_gemma":[0.9958271,0.0002359971,0.00165945,0.00006316907,0.000009816411,0.00002878355,0.0008248546,0.00002219085,0.001328603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007051475,"threshold_uncertainty_score":0.002211332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168324967652032,"score_gpt":0.2658665999164253,"score_spread":0.254183350239905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}