{"id":"W1891037876","doi":"10.1111/j.1399-0004.2004.00315.x","title":"Hutchinson–Gilford progeria syndrome","year":2004,"lang":"en","type":"review","venue":"Clinical Genetics","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"LMNA; Progeria; Lamin; Biology; Genetics; Premature aging; Nuclear lamina; Point mutation; Mutation; Exon; Gene; Nuclear protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002702948,0.0004371016,0.001103613,0.00004566062,0.00007125486,0.00004090283,0.000437497,0.001295486,0.00005985229],"category_scores_gemma":[0.0001405328,0.0003603314,0.0009219007,0.0001270666,0.0001655398,0.000001241075,0.0002565855,0.0004913906,0.0002721823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002416591,"about_ca_system_score_gemma":0.0004261016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.068497e-7,"about_ca_topic_score_gemma":0.000003001531,"domain_scores_codex":[0.9976108,0.0001557146,0.0009760822,0.0007709138,0.0001542423,0.0003322694],"domain_scores_gemma":[0.9984602,0.00002850563,0.000363265,0.0008944623,0.00005898669,0.0001945744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001289843,0.00008191001,0.00002619849,0.002442376,0.0002675479,0.00002588179,0.000002195806,0.000002485155,0.000006049838,0.00004872588,0.002043981,0.9950398],"study_design_scores_gemma":[0.0002550826,0.0006007066,0.00005224852,0.0009714243,0.0004664884,0.0002541831,0.00000157449,7.343621e-7,0.000005282718,0.0001393766,0.996838,0.0004148515],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005140626,0.9962621,0.0001469508,0.00001198565,0.001871463,0.0005652373,0.00004480461,0.00002951032,0.0005539101],"genre_scores_gemma":[0.00006174003,0.9938467,0.003027573,0.0001390202,0.0009666499,0.00002943367,0.0005172194,0.0001199733,0.001291748],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9947941,"threshold_uncertainty_score":0.9998848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07006326715358303,"score_gpt":0.4065157341953015,"score_spread":0.3364524670417184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}