{"id":"W1891037876","doi":"10.1111/j.1399-0004.2004.00315.x","title":"Hutchinson–Gilford progeria syndrome","year":2004,"lang":"en","type":"review","venue":"Clinical Genetics","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"LMNA; Progeria; Lamin; Biology; Genetics; Premature aging; Nuclear lamina; Point mutation; Mutation; Exon; Gene; Nuclear protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000215528,0.001052085,0.000972341,0.001668252,0.0002817997,0.0005161384,0.0005879346,0.0009127476,0.004165433],"category_scores_gemma":[0.0003660886,0.0001799875,0.000197391,0.001450012,0.0003416506,0.0009006904,0.0004237375,0.001073404,0.003814777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005335265,"about_ca_system_score_gemma":0.0005893843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097506,"about_ca_topic_score_gemma":0.002292752,"domain_scores_codex":[0.9999137,0.00001136764,0.00001015136,0.00001771816,0.00003524981,0.0000117546],"domain_scores_gemma":[0.9999229,0.0000238034,0.00001315983,0.000003747077,0.00001889218,0.00001767603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006555534,0.00004916789,0.000339486,0.003246228,0.00004462891,0.001778235,0.00003925206,0.0001960732,0.00147984,0.001694713,0.06902248,0.9220442],"study_design_scores_gemma":[0.00002416283,0.0000435488,0.001607181,0.0007879401,0.00003528799,0.01031678,0.00003483795,0.00004399085,0.0003537079,0.0009841438,0.9857588,0.000009706919],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004718736,0.991516,0.000381591,0.0007417705,0.0006216199,0.00001013017,0.00003302023,0.00003889517,0.006185071],"genre_scores_gemma":[0.002796073,0.988278,0.0004677813,0.0006315909,0.0004606856,0.00001675013,0.0001103526,0.000004835468,0.007233982],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004165433,"threshold_uncertainty_score":0.01393479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07006326715358303,"score_gpt":0.4065157341953015,"score_spread":0.3364524670417184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}