{"id":"W1891508715","doi":"10.1111/j.1462-5822.2011.01640.x","title":"The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300","year":2011,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Biology; Secretion; Virulence; Effector; Microbiology; Metalloproteinase; Enteropathogenic Escherichia coli; Escherichia coli; Type three secretion system; Protease; Virulence factor; Cell biology; Gene; Matrix metalloproteinase; Enzyme; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006027922,0.0003243913,0.0002483281,0.00002944663,0.000703516,0.00003810916,0.0008397206,0.0002844812,0.00007868887],"category_scores_gemma":[0.0002645875,0.0001909173,0.0001837631,0.0002699122,0.0009758018,0.000004223425,0.0003657465,0.0003982637,0.00006945492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002476591,"about_ca_system_score_gemma":0.0002502089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006957835,"about_ca_topic_score_gemma":0.0002062745,"domain_scores_codex":[0.997755,0.0005835037,0.0003139692,0.0005304826,0.00007942237,0.0007376195],"domain_scores_gemma":[0.9986306,0.0000732581,0.00009955666,0.0008460035,0.0002312621,0.0001192757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003945592,0.00006643471,0.0006658546,0.00001491152,0.0002369861,0.00001494698,0.0002721454,5.088993e-7,0.9964056,0.0001706742,0.001553459,0.0002039124],"study_design_scores_gemma":[0.0007076829,0.0005994279,0.001528428,0.000008689002,0.00005776692,0.00002944315,0.0003433557,0.000014146,0.8820182,0.00004946156,0.1143287,0.0003146998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863225,0.01061457,0.0003975695,0.0004677707,0.0003107951,0.001012892,0.00004041866,0.00003334433,0.0008001102],"genre_scores_gemma":[0.9952402,0.001488992,0.0002967874,0.0004846231,0.0001924704,0.0001960952,0.0001408132,0.00004795914,0.001912035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1143874,"threshold_uncertainty_score":0.7785382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887884825704766,"score_gpt":0.2293440227679777,"score_spread":0.2104651745109301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}