{"id":"W1892828309","doi":"10.1002/pbc.25705","title":"Hydroxyurea Therapy for Children With Sickle Cell Anemia in Sub‐Saharan Africa: Rationale and Design of the REACH Trial","year":2015,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Center for Advancing Translational Sciences; Hospital for Sick Children; Wellcome Trust; National Heart, Lung, and Blood Institute; Cincinnati Children's Hospital Medical Center","keywords":"Medicine; Clinical trial; Sickle cell anemia; Anemia; Disease; Disease burden; Clinical endpoint; Blood cancer; Pediatrics; Intensive care medicine; Family medicine; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02211214,0.002039623,0.002448025,0.0007064932,0.001216379,0.001853791,0.001413081,0.002511178,0.006772153],"category_scores_gemma":[0.01631525,0.0008222626,0.002335879,0.00103886,0.00214492,0.001580761,0.001315934,0.003151874,0.001517699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001216535,"about_ca_system_score_gemma":0.005353365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000554805,"about_ca_topic_score_gemma":0.001424422,"domain_scores_codex":[0.9877419,0.009927612,0.0006714527,0.000573057,0.0006010136,0.0004849272],"domain_scores_gemma":[0.995769,0.001694084,0.000929341,0.0004282852,0.0004528588,0.0007264529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.6491256,0.01893915,0.02718332,0.04429051,0.00981678,0.001377736,0.001942196,0.00755256,0.006384106,0.03130396,0.02312527,0.1789588],"study_design_scores_gemma":[0.757271,0.08320703,0.01288051,0.0106287,0.008127348,0.0006958711,0.0006601158,0.003281757,0.002293523,0.01598245,0.1047977,0.0001740573],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1459483,0.03708159,0.01605831,0.01389441,0.003053401,0.7499751,0.006363499,0.0002605978,0.02736481],"genre_scores_gemma":[0.2185895,0.01058555,0.02577275,0.007198158,0.001035268,0.7326496,0.001486001,0.00003672634,0.002646575],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02211214,"threshold_uncertainty_score":0.1169416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122319249123454,"score_gpt":0.2371459769868888,"score_spread":0.2159227844956543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}