{"id":"W1892860126","doi":"10.4049/jimmunol.1403247","title":"Polycomb Repressive Complex 2 Confers BRG1 Dependency on the <i>CIITA</i> Locus","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"CIITA; PRC2; Chromatin remodeling; Repressor; Cancer research; Histone; Gene knockdown; Cell biology; RELB; Chromatin; Biology; Genetics; Histone H3; Immune system; Gene; Gene expression; MHC class II; Transcription factor; NFKB1; Major histocompatibility complex","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000085329,0.0003543411,0.0002016545,0.0002326513,0.0001781449,0.0003196574,0.0002908153,0.0001865314,0.002355955],"category_scores_gemma":[0.00008967044,0.0002159091,0.0002870108,0.0001220093,0.0002486081,0.0001560508,0.0003975857,0.0006770071,0.0007565788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000339845,"about_ca_system_score_gemma":0.0001582802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008667203,"about_ca_topic_score_gemma":0.001733734,"domain_scores_codex":[0.9998052,0.00002061019,0.00001946553,0.00005190482,0.00005770281,0.0000451848],"domain_scores_gemma":[0.9998389,0.0000182524,0.00005307147,0.000032791,0.000009936008,0.00004700042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000018948,0.000002654724,0.00005321015,0.000007013402,0.000001548277,0.00001258334,0.000003546814,0.00001405806,0.9996212,0.00003490196,0.000008447581,0.0002219643],"study_design_scores_gemma":[0.000004046121,0.00003607652,0.004051754,0.000001552938,0.000004739761,0.0001378082,0.000007726318,0.000261387,0.9944343,0.00001488235,0.001043379,0.000002439318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916625,0.000923511,0.003732733,0.00008973665,0.00003698884,0.00001344797,0.0005105943,0.0002339727,0.002796493],"genre_scores_gemma":[0.9943824,0.0002857286,0.001036839,0.00004094112,0.000007578208,0.00001148969,0.0007301402,0.00006632401,0.003438614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355955,"threshold_uncertainty_score":0.007881463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03622980812271298,"score_gpt":0.2727257677657438,"score_spread":0.2364959596430308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}