{"id":"W1892860126","doi":"10.4049/jimmunol.1403247","title":"Polycomb Repressive Complex 2 Confers BRG1 Dependency on the <i>CIITA</i> Locus","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"CIITA; PRC2; Chromatin remodeling; Repressor; Cancer research; Histone; Gene knockdown; Cell biology; RELB; Chromatin; Biology; Genetics; Histone H3; Immune system; Gene; Gene expression; MHC class II; Transcription factor; NFKB1; Major histocompatibility complex","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006094669,0.0001077048,0.0001553701,0.00002337875,0.00009001691,0.00001264909,0.0005086785,0.0000950347,0.00003649002],"category_scores_gemma":[0.0002407049,0.00005545733,0.0000937553,0.00004258817,0.0001998025,0.000002809064,0.000097469,0.0002671837,0.00001886538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002707171,"about_ca_system_score_gemma":0.0001892068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000045242,"about_ca_topic_score_gemma":0.000009383573,"domain_scores_codex":[0.9990352,0.000284182,0.0002734412,0.0000883908,0.0001490989,0.0001697052],"domain_scores_gemma":[0.9989188,0.00006719473,0.0003136913,0.000407489,0.0002513416,0.00004144135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001249707,0.00008094597,0.00009634686,0.000003093289,0.0003968964,0.00001293157,0.000545741,0.001193989,0.9475689,0.0005811922,0.04317961,0.005090656],"study_design_scores_gemma":[0.006549782,0.006243781,0.00174683,0.0001519561,0.0003140846,0.005193088,0.007369204,0.0004399169,0.8265067,0.00959219,0.1352402,0.0006522948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841678,0.005796225,0.0008460106,0.004475509,0.0004714698,0.00008161059,0.000005239584,0.000004501753,0.004151679],"genre_scores_gemma":[0.9975138,0.0006429154,0.00005525642,0.001194582,0.000252356,0.000001474198,0.000003177329,0.00001217051,0.0003242958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1210622,"threshold_uncertainty_score":0.2261484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03622980812271298,"score_gpt":0.2727257677657438,"score_spread":0.2364959596430308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}