{"id":"W189328732","doi":"10.1038/npre.2010.4507.1","title":"EAG K+ channel joins the p53&x2212;miR-34&x2212;E2F1 signaling pathway as a terminal effecter component for its oncogenic overexpression and action","year":2010,"lang":"en","type":"preprint","venue":"Nature Precedings","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Gene silencing; Gene knockdown; Transactivation; Downregulation and upregulation; E2F1; Molecular biology; Biology; Cell biology; RNA interference; Carcinogenesis; Cell growth; Signal transduction; Chemistry; Gene expression; Cancer research; Gene; RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009388089,0.0005215821,0.0002130283,0.000174514,0.0002105223,0.0002859988,0.0001206113,0.0002558593,0.002334765],"category_scores_gemma":[0.00007403337,0.0001402551,0.0002461493,0.00009045671,0.0001698528,0.0002186465,0.0001691661,0.0005003902,0.0006556679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003148579,"about_ca_system_score_gemma":0.0001499409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003328768,"about_ca_topic_score_gemma":0.0003621634,"domain_scores_codex":[0.9999074,0.00001350584,0.000006865962,0.00002220392,0.00002425251,0.00002585174],"domain_scores_gemma":[0.9999564,0.000005506366,0.00001202433,0.000005801684,0.000006039376,0.00001421167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008538028,0.00001625995,0.0001095025,0.00001992916,0.000002754118,0.00005442884,0.000005259085,0.00003322317,0.9986416,0.0001725692,0.00004605547,0.0008130888],"study_design_scores_gemma":[0.00001565683,0.00009589239,0.00224193,0.000003509243,0.000009142252,0.0001696361,0.00001402331,0.0008259037,0.9925418,0.00006091304,0.004018768,0.000002833702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814558,0.003520822,0.009829383,0.0003186914,0.0001138784,0.00005714133,0.0006360809,0.000432302,0.003636006],"genre_scores_gemma":[0.9908867,0.0006816934,0.002139091,0.00005419589,0.00001065499,0.00003315163,0.0005113404,0.0000235534,0.0056596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002334765,"threshold_uncertainty_score":0.007810593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02662732402850402,"score_gpt":0.3044537099983911,"score_spread":0.2778263859698871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}