{"id":"W1893889089","doi":"10.1186/s13287-015-0122-1","title":"Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn’s disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact","year":2015,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"Università degli Studi di Pavia; Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali","keywords":"Mesenchymal stem cell; FOXP3; Indoleamine 2,3-dioxygenase; Immunology; T cell; IL-2 receptor; Stem cell; Biology; Cancer research; Immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009820901,0.0004577507,0.0005074426,0.0002091319,0.0001991399,0.00008554692,0.0005024847,0.0003229189,0.00002789364],"category_scores_gemma":[0.00001220572,0.000387168,0.0001741433,0.000171562,0.000168197,0.00001676908,0.0002665577,0.0006354459,0.00006528563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000128241,"about_ca_system_score_gemma":0.000599346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002197942,"about_ca_topic_score_gemma":0.00004041027,"domain_scores_codex":[0.9957198,0.001233713,0.000353863,0.000932017,0.0008063155,0.0009542833],"domain_scores_gemma":[0.9972805,0.0002761777,0.000275627,0.0009778907,0.000375255,0.0008145891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005986094,0.001636861,0.000278403,0.0006208526,0.00005534372,0.0002269141,0.000365682,0.00002862603,0.9852903,0.000005931557,0.004430236,0.001074759],"study_design_scores_gemma":[0.005576795,0.003819605,0.003919553,0.0001140976,0.00001043528,0.000001946641,0.0004681987,0.00002037281,0.9823943,0.000007415292,0.003312717,0.0003545074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910045,0.005794311,0.0000224183,0.00007674431,0.0002621144,0.001707302,0.0002800008,0.00001693968,0.0008357016],"genre_scores_gemma":[0.9918437,0.003364055,0.00001661391,0.0001457917,0.0001661567,0.00005829255,0.00003098787,0.00007995825,0.004294422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00364115,"threshold_uncertainty_score":0.999858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03073086072416106,"score_gpt":0.3043078964847004,"score_spread":0.2735770357605393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}