{"id":"W1893889089","doi":"10.1186/s13287-015-0122-1","title":"Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn’s disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact","year":2015,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"Università degli Studi di Pavia; Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali","keywords":"Mesenchymal stem cell; FOXP3; Indoleamine 2,3-dioxygenase; Immunology; T cell; IL-2 receptor; Stem cell; Biology; Cancer research; Immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002370205,0.000391821,0.0004351247,0.0002646531,0.00009072718,0.0002772675,0.0001104361,0.0002095054,0.001181323],"category_scores_gemma":[0.0001142438,0.0000986225,0.0003105593,0.0001311861,0.0002212039,0.000137868,0.0001485533,0.0005752849,0.0002766296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007717466,"about_ca_system_score_gemma":0.0001420025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000133257,"about_ca_topic_score_gemma":0.00026601,"domain_scores_codex":[0.9997254,0.00006763292,0.00003526059,0.00003767488,0.0000688193,0.00006526501],"domain_scores_gemma":[0.9998642,0.00004288845,0.00002588993,0.00001789303,0.00001532438,0.00003377685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005880232,0.0001886549,0.0002434863,0.00009429672,0.000008101771,0.00007871598,0.00004053536,0.00005064732,0.9958895,0.00004216,0.00002670772,0.00274926],"study_design_scores_gemma":[0.0001026586,0.003621249,0.006367192,0.00001882758,0.00005611941,0.0001977047,0.00004424913,0.0004194675,0.9876921,0.0000335378,0.001443542,0.000003436928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959397,0.001917206,0.0008724586,0.00004150221,0.00004692745,0.00002837921,0.0001422898,0.00002985899,0.0009817607],"genre_scores_gemma":[0.996624,0.001013838,0.001010229,0.00004016959,0.00003034456,0.00005035489,0.0003173977,0.000008135095,0.0009055223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181323,"threshold_uncertainty_score":0.003951967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03073086072416106,"score_gpt":0.3043078964847004,"score_spread":0.2735770357605393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}