{"id":"W1894320934","doi":"10.1128/mbio.00861-15","title":"CRISPR-Cas9-Mediated Genome Editing in Leishmania donovani","year":2015,"lang":"en","type":"article","venue":"mBio","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Biology; Cas9; Genome editing; Guide RNA; Leishmania donovani; Genetics; Gene; Computational biology; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002011942,0.0006043193,0.0003289507,0.0002305452,0.000257969,0.0004464273,0.0005005133,0.0005060057,0.001751737],"category_scores_gemma":[0.0001030166,0.0001763825,0.0002789765,0.000166785,0.0003502778,0.0001634511,0.000492198,0.0005722643,0.0009201877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003936266,"about_ca_system_score_gemma":0.0002947817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000462479,"about_ca_topic_score_gemma":0.0007727087,"domain_scores_codex":[0.9997939,0.00003844225,0.00001886954,0.00006131974,0.00004779436,0.00003965316],"domain_scores_gemma":[0.9999502,0.000007049439,0.00001512662,0.000006625759,0.000008659274,0.00001232636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001225169,0.0000362493,0.0003078317,0.0003077625,0.00001391164,0.0002650939,0.00003344701,0.0005284142,0.9889431,0.0007331496,0.0003894331,0.008319162],"study_design_scores_gemma":[0.00004998258,0.0002351979,0.001019948,0.0000279313,0.00004188993,0.000947243,0.00003870329,0.003002904,0.9612644,0.000178315,0.03317633,0.00001725904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8406251,0.01689071,0.1117049,0.001266464,0.0007663791,0.0004770704,0.002251226,0.003120058,0.02289809],"genre_scores_gemma":[0.9534262,0.002676867,0.03279706,0.000221548,0.00002861107,0.0001418913,0.001710367,0.0001260584,0.008871319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001751737,"threshold_uncertainty_score":0.005860209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358481540404784,"score_gpt":0.2830346327586065,"score_spread":0.2694498173545587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}