{"id":"W1894488566","doi":"10.4049/jimmunol.181.2.1096","title":"Critical Role of CD4 Help in CD154 Blockade-Resistant Memory CD8 T Cell Activation and Allograft Rejection in Sensitized Recipients","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; American Heart Association","keywords":"CD154; Blockade; CD8; Immunology; Cytotoxic T cell; Medicine; Biology; CD40; Immune system; Internal medicine; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960714,0.0004155239,0.0002642875,0.0002317226,0.0001451208,0.000379986,0.0001965732,0.0002772897,0.001232442],"category_scores_gemma":[0.000165363,0.0001494933,0.0001952753,0.00006760244,0.0002244654,0.000196742,0.0001756781,0.0007989392,0.0002991879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001744523,"about_ca_system_score_gemma":0.0001890314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001413185,"about_ca_topic_score_gemma":0.0002107257,"domain_scores_codex":[0.9997532,0.00005937672,0.0000284972,0.00004670338,0.0000494581,0.00006285652],"domain_scores_gemma":[0.9998429,0.00002932345,0.00004840293,0.0000199363,0.00001371469,0.00004571244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001165657,0.00005914807,0.0003959372,0.00001710795,0.000003193227,0.00005021277,0.00001121912,0.00003815239,0.9984024,0.000052344,0.00001236671,0.0008413],"study_design_scores_gemma":[0.00003977752,0.001053216,0.009698243,0.00001202365,0.00004155011,0.0006033322,0.00004372783,0.000724234,0.9864582,0.00007952003,0.001241462,0.000004660727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976293,0.0007277029,0.0008966773,0.00005696812,0.00001136318,0.00001816235,0.00005108177,0.00004170939,0.0005670902],"genre_scores_gemma":[0.9973837,0.0003187788,0.0009171877,0.00005273238,0.00001374438,0.00002701103,0.0001067905,0.00001199393,0.001168037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001232442,"threshold_uncertainty_score":0.004122913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00931385176608198,"score_gpt":0.2198619704951666,"score_spread":0.2105481187290846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}