{"id":"W1894529683","doi":"10.1128/jvi.01793-15","title":"Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Japan Society for the Promotion of Science; National Institutes of Health; Eusko Jaurlaritza; Diamond Light Source","keywords":"Epitope; Biology; Antibody; Human immunodeficiency virus (HIV); Virology; Basis (linear algebra); Computational biology; Immunology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693232,0.0003728843,0.0002639065,0.0001505884,0.0003266789,0.0002873199,0.0007830995,0.0003128898,0.001877269],"category_scores_gemma":[0.0003621023,0.0001883406,0.0002322052,0.0001159894,0.0004169899,0.0002126601,0.0002281338,0.0004874,0.0002363581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007226177,"about_ca_system_score_gemma":0.0003197067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002837209,"about_ca_topic_score_gemma":0.001939102,"domain_scores_codex":[0.9998593,0.00001673851,0.000004976126,0.00002262507,0.00006127307,0.00003503214],"domain_scores_gemma":[0.9998522,0.0000535843,0.00003056952,0.000009272318,0.00003450378,0.00002003464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006233361,0.0002257011,0.009633403,0.0001406035,0.00007545073,0.0002609623,0.00007923805,0.02418229,0.9571728,0.001501057,0.0002362987,0.0058688],"study_design_scores_gemma":[0.0001140998,0.0009468549,0.02058217,0.00001290497,0.0000790224,0.0005732336,0.0001556762,0.1122486,0.8623505,0.001211743,0.001681872,0.00004336831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973443,0.000202568,0.001682733,0.00002999103,0.000004431425,0.000006930596,0.00005893462,0.00001758541,0.0006526284],"genre_scores_gemma":[0.9988172,0.00007654245,0.0007186038,0.00001856338,0.000001825321,0.000007706576,0.0001787255,0.000007006426,0.0001739592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002837209,"threshold_uncertainty_score":0.006280124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705874311634882,"score_gpt":0.2796333486550708,"score_spread":0.262574605538722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}