{"id":"W1894740506","doi":"10.1111/mmi.12644","title":"The three major types of <scp>CRISPR</scp>‐<scp>Cas</scp> systems function independently in <scp>CRISPR RNA</scp> biogenesis in <scp><i>S</i></scp><i>treptococcus thermophilus</i>","year":2014,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Institutes of Health; China Scholarship Council","keywords":"Trans-activating crRNA; CRISPR; Biogenesis; Biology; Locus (genetics); RNA; Genetics; Cas9; Gene; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001381599,0.00106143,0.001181783,0.0005437549,0.0002443201,0.0001335025,0.001340209,0.001418754,0.000004185285],"category_scores_gemma":[0.002233316,0.0009520961,0.0005446529,0.0008928529,0.0004332379,0.0000263017,0.000689378,0.0007541042,0.00009095349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000120512,"about_ca_system_score_gemma":0.0001886868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004410069,"about_ca_topic_score_gemma":0.001161815,"domain_scores_codex":[0.9939907,0.0007644049,0.001477801,0.001636051,0.000339812,0.001791266],"domain_scores_gemma":[0.9959273,0.001116732,0.0006286521,0.001699185,0.0003402374,0.0002879058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001440519,0.0002085401,0.008958903,0.0001699064,0.0003923252,0.00004785301,0.0003567543,0.004236042,0.978133,0.0002514645,0.00655984,0.0006709943],"study_design_scores_gemma":[0.002167774,0.0007216779,0.007055635,0.0001151753,0.0001872289,0.0001653149,0.001379224,0.0003781788,0.8368853,0.0002394437,0.1505577,0.0001473089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514881,0.02453043,0.01833281,0.00005888118,0.001551809,0.001488262,0.0001992181,0.0000926896,0.002257769],"genre_scores_gemma":[0.995633,0.00104848,0.0002550798,0.0004392684,0.000436572,0.0003280595,0.0005300996,0.0002241892,0.001105244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1439979,"threshold_uncertainty_score":0.9998776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004721626667271593,"score_gpt":0.2255441397489824,"score_spread":0.2208225130817107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}