{"id":"W1894740506","doi":"10.1111/mmi.12644","title":"The three major types of <scp>CRISPR</scp>‐<scp>Cas</scp> systems function independently in <scp>CRISPR RNA</scp> biogenesis in <scp><i>S</i></scp><i>treptococcus thermophilus</i>","year":2014,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Institutes of Health; China Scholarship Council","keywords":"Trans-activating crRNA; CRISPR; Biogenesis; Biology; Locus (genetics); RNA; Genetics; Cas9; Gene; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427955,0.0004074276,0.000381849,0.0003709148,0.000230421,0.0004775529,0.0002587822,0.0003614947,0.001017663],"category_scores_gemma":[0.0003624743,0.0002563904,0.0005721407,0.0003475588,0.0003498776,0.0001991222,0.0004081231,0.000627749,0.0004055995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003094265,"about_ca_system_score_gemma":0.0003781313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007286109,"about_ca_topic_score_gemma":0.001156688,"domain_scores_codex":[0.9997087,0.00003038744,0.00004248428,0.00006398134,0.0001016395,0.00005275736],"domain_scores_gemma":[0.9996811,0.00004614116,0.0001204835,0.00005264242,0.00003685696,0.00006285241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000855289,0.00001580159,0.001598503,0.00005925442,0.00001254564,0.00006268108,0.00003353432,0.0001594289,0.9942101,0.0002520688,0.00005328661,0.00345724],"study_design_scores_gemma":[0.00001166343,0.0002154175,0.01902253,0.000009950978,0.00003592683,0.0007042293,0.00005598288,0.001388843,0.9755539,0.0001286551,0.002850805,0.00002216863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842303,0.0006852763,0.01111204,0.00009004317,0.00002162166,0.0001037971,0.0007481782,0.000309854,0.002698755],"genre_scores_gemma":[0.9800301,0.000284679,0.01544572,0.00007701254,0.000006306424,0.00009504067,0.001523771,0.00005146371,0.002485829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001017663,"threshold_uncertainty_score":0.003404438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004721626667271593,"score_gpt":0.2255441397489824,"score_spread":0.2208225130817107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}