{"id":"W1894823067","doi":"10.1001/jamapsychiatry.2015.1131","title":"Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence","year":2015,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Centre Hospitalier Universitaire Sainte-Justine; Cégep de Jonquière; Université du Québec à Chicoutimi; University of Calgary; McGill University; SickKids Foundation; University of Toronto; Montreal Neurological Institute and Hospital; Baycrest Hospital","funders":"National Institute of Mental Health; Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Cannabis; Polygenic risk score; Schizophrenia (object-oriented programming); Longitudinal study; Psychology; Population; Prodrome; Young adult; Psychiatry; Medicine; Clinical psychology; Psychosis; Developmental psychology; Biology; Single-nucleotide polymorphism; Environmental health; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005055616,0.0002582599,0.0001793511,0.0007448292,0.0004920264,0.0004045326,0.0002767151,0.0002654314,0.001605584],"category_scores_gemma":[0.001972277,0.0001652007,0.0003464587,0.0006854329,0.0003310279,0.0002185282,0.000402548,0.0003801312,0.00008946008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004552454,"about_ca_system_score_gemma":0.0009792122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.06107238,"about_ca_topic_score_gemma":0.08315613,"domain_scores_codex":[0.9997293,0.00006702026,0.00002145899,0.00006011154,0.00006678094,0.00005537671],"domain_scores_gemma":[0.9989361,0.000161408,0.000504379,0.00006718919,0.0001222578,0.0002085624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004525487,0.000008500154,0.9987727,0.000003364485,0.00002861842,0.0000458234,0.00005198228,0.00002513109,0.0002546095,0.00002132045,0.0000250042,0.0007175933],"study_design_scores_gemma":[6.977713e-7,0.00001171603,0.9997699,0.000002405265,0.000006770617,0.00005412386,0.00003185355,0.00005980063,0.00002696737,0.00001100581,0.00002410038,7.95281e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992392,0.0001446582,0.00008271218,0.00003765258,0.000001752587,0.000005834936,0.0002465322,0.000002684714,0.0002389871],"genre_scores_gemma":[0.9995689,0.00007214022,0.00009905734,0.000004759816,0.000001776946,0.000004061993,0.0001692127,0.000001198503,0.00007886032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06107238,"threshold_uncertainty_score":0.1214338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02238410525529095,"score_gpt":0.2904089837774749,"score_spread":0.268024878522184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}