{"id":"W1895220657","doi":"10.1089/aid.2015.0182","title":"Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)","year":2015,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center for AIDS Research, University of North Carolina at Chapel Hill; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; Partenariat Canadien Contre Le Cancer; Georgia Clinical and Translational Science Alliance","keywords":"Dosing; Medicine; Emtricitabine; Pharmacokinetics; Peripheral blood mononuclear cell; Pre-exposure prophylaxis; Cmin; Pharmacology; Area under the curve; Urology; Internal medicine; Human immunodeficiency virus (HIV); Cmax; Men who have sex with men; Viral load; Immunology; Antiretroviral therapy; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001686982,0.0006104137,0.001125311,0.0002252455,0.0002935642,0.0005145624,0.0005990001,0.0008582175,0.001853919],"category_scores_gemma":[0.002367342,0.0005478074,0.0006140794,0.0002246373,0.00050491,0.0005885283,0.0003459586,0.00184215,0.000494839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003779718,"about_ca_system_score_gemma":0.000499661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008898278,"about_ca_topic_score_gemma":0.0008147571,"domain_scores_codex":[0.9989148,0.0005796989,0.00004178305,0.0001966703,0.0001500454,0.0001169555],"domain_scores_gemma":[0.9991742,0.0002346551,0.0001854223,0.00013177,0.00008464285,0.0001892576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5508401,0.1409581,0.0157552,0.0004525456,0.0008529747,0.0001653539,0.0006673773,0.002752051,0.1555131,0.000265815,0.001999347,0.129778],"study_design_scores_gemma":[0.04280778,0.8961147,0.04345172,0.00001507686,0.0002177655,0.0002318825,0.00005964823,0.002620802,0.01306141,0.0001142373,0.001260302,0.00004470417],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975178,0.0002993965,0.0006748644,0.0000483312,0.0000416087,0.0006748477,0.0002557225,0.00004620516,0.000441116],"genre_scores_gemma":[0.9962994,0.0002241496,0.001409295,0.0001306209,0.00005563435,0.000524982,0.0003153966,0.00001120098,0.001029204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001853919,"threshold_uncertainty_score":0.008921683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1476058121221151,"score_gpt":0.4279001631183549,"score_spread":0.2802943509962398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}