{"id":"W1895889333","doi":"10.1073/pnas.1510757112","title":"ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"ALDH2; Acetaldehyde; Aldehyde dehydrogenase; Carcinogen; Ethanol metabolism; Hepatocellular carcinoma; Genome instability; Biology; Cancer research; DNA damage; Liver injury; Genetics; Ethanol; Endocrinology; Biochemistry; Gene; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001275592,0.00007792091,0.0001590618,0.0001534691,0.0001039371,0.00001196288,0.0001375074,0.00006317344,0.00001017754],"category_scores_gemma":[0.001376546,0.00004933785,0.0000340096,0.0004073004,0.0004984235,0.0002569108,0.00006970542,0.00009959438,0.000001879755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003792162,"about_ca_system_score_gemma":0.0001065741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003651954,"about_ca_topic_score_gemma":1.909773e-7,"domain_scores_codex":[0.9985269,0.000009008435,0.0002421776,0.0001788212,0.0009287533,0.0001143108],"domain_scores_gemma":[0.9991261,0.00006582138,0.0002656151,0.00000651193,0.000434062,0.0001018269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003402687,0.000312663,0.4822581,0.001416752,0.00004993965,1.315346e-7,0.0007950945,0.000005280884,0.4784042,0.03178886,0.001425997,0.003202766],"study_design_scores_gemma":[0.0008504302,0.0002601321,0.7217811,0.00033894,0.0000335374,0.00008208757,0.0001405815,0.0009182438,0.2649382,0.01042156,0.0001580188,0.00007719495],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923249,0.0003582632,5.161709e-7,0.005171943,0.000007028164,0.0005754512,0.00000463744,0.00001497464,0.001542247],"genre_scores_gemma":[0.9979858,0.00001211287,0.001325361,0.0004510819,0.00006231374,0.00002741592,2.376717e-7,0.000003834677,0.0001318275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.239523,"threshold_uncertainty_score":0.2011939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1453888606667902,"score_gpt":0.3796040800621648,"score_spread":0.2342152193953746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}