{"id":"W1896531240","doi":"10.4049/jimmunol.178.9.5480","title":"Immune Modulation and Tolerance Induction by RelB-Silenced Dendritic Cells through RNA Interference","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"","keywords":"RELB; Immune tolerance; Immune system; Cell biology; CD80; CD86; Gene silencing; Biology; Small interfering RNA; RNA interference; Dendritic cell; FOXP3; Immunology; Chemistry; Cancer research; T cell; In vitro; RNA; CD40; Transfection; NFKB1; Cytotoxic T cell; Cell culture; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002057646,0.0003528069,0.0003030728,0.0002073518,0.0001774772,0.0003790878,0.0002579978,0.0002383957,0.0008725916],"category_scores_gemma":[0.0001465528,0.0001701069,0.0002446873,0.0001215006,0.0003530501,0.0001451961,0.0001869629,0.0007728519,0.0003092931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212666,"about_ca_system_score_gemma":0.0001602754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001664024,"about_ca_topic_score_gemma":0.0002424401,"domain_scores_codex":[0.9997587,0.0000535392,0.00002670311,0.00005322026,0.00005212205,0.00005574697],"domain_scores_gemma":[0.9998825,0.00003405895,0.00003710585,0.00001780545,0.000009895258,0.00001870824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004606949,0.00002344483,0.00004502375,0.00002133864,0.000002390932,0.00002568196,0.000007897029,0.00003912553,0.9987968,0.00009569875,0.00002660339,0.0008698941],"study_design_scores_gemma":[0.00002221784,0.0001574234,0.0003919479,0.000003189895,0.00001062631,0.0001131267,0.000009434048,0.0005481017,0.9972067,0.00003290687,0.001502176,0.00000211927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847865,0.002580621,0.009166131,0.0002124821,0.0001158588,0.0000750609,0.0002768156,0.0002003167,0.002586269],"genre_scores_gemma":[0.9923707,0.001169353,0.004147011,0.00008744303,0.00002975284,0.00007426079,0.0002750558,0.00004522515,0.00180116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008725916,"threshold_uncertainty_score":0.002919078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207222329701088,"score_gpt":0.2456732174883992,"score_spread":0.2336009941913883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}