{"id":"W1896715962","doi":"10.1080/15548627.2015.1040969","title":"Macroautophagy is essential for killing of intracellular<i>Burkholderia pseudomallei</i>in human neutrophils","year":2015,"lang":"en","type":"article","venue":"Autophagy","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Associated Medical Services","funders":"National Institute of Allergy and Infectious Diseases; Biotechnology and Biological Sciences Research Council","keywords":"Burkholderia pseudomallei; Biology; Melioidosis; Phagosome; Microbiology; Secretion; Intracellular parasite; Autophagy; Intracellular; Pathogen; Phagocytosis; Bacteria; Cell biology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004178234,0.0002505979,0.0006263012,0.00032063,0.00007999553,0.00002604747,0.0001418151,0.0002244042,0.0002589173],"category_scores_gemma":[0.00007035113,0.0002461711,0.000245422,0.0003878205,0.0001124858,0.0001296816,0.00005827862,0.0002056468,0.00002012085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009488609,"about_ca_system_score_gemma":0.0001809623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003238701,"about_ca_topic_score_gemma":0.00001448313,"domain_scores_codex":[0.9981315,0.00004171353,0.0006715459,0.0004305581,0.0002686587,0.0004560254],"domain_scores_gemma":[0.9987705,0.00005369414,0.000192608,0.0004778687,0.0002617951,0.0002435674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003069084,0.0009019757,0.001581768,0.0003239163,0.0001514134,0.00009441087,0.001054102,0.0001327463,0.9813857,0.006003587,0.004031938,0.004031535],"study_design_scores_gemma":[0.008452038,0.00099797,0.003997832,0.0001724009,0.0002212436,0.0001270151,0.0002520229,0.002371383,0.9638523,0.001650855,0.01756715,0.0003377866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919934,0.0009334002,0.003175527,0.0005579127,0.0008537646,0.0008586213,0.00002144162,0.00009398227,0.001511905],"genre_scores_gemma":[0.9941531,0.0000609205,0.00352562,0.000331099,0.0005101505,0.0001279726,0.00004298564,0.00005913774,0.001188985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0175334,"threshold_uncertainty_score":0.999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03742854270272675,"score_gpt":0.315521124247557,"score_spread":0.2780925815448302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}