{"id":"W1897393730","doi":"10.1111/ajt.12926","title":"Recurrent 2,8-Dihydroxyadenine Nephropathy: A Rare but Preventable Cause of Renal Allograft Failure","year":2014,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Public Health Service; National Institutes of Health; Rare Diseases Clinical Research Network","keywords":"Medicine; Adenine phosphoribosyltransferase; Nephropathy; Transplantation; Crystalluria; Gastroenterology; Chronic allograft nephropathy; Renal function; Urology; Kidney transplantation; Tubulopathy; Kidney disease; Internal medicine; Nephrology; Allopurinol; Pathology; Surgery; Endocrinology; Purine; Urinary system; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002187921,0.0006052589,0.0008044948,0.0007605441,0.0006638397,0.0006554268,0.0008443077,0.001745022,0.001504146],"category_scores_gemma":[0.002462576,0.000287792,0.0003978386,0.000532646,0.0005878648,0.0006100775,0.0004854637,0.001164049,0.0006623906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002320901,"about_ca_system_score_gemma":0.0004068193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000660818,"about_ca_topic_score_gemma":0.0006562803,"domain_scores_codex":[0.9996741,0.00004907546,0.00003460624,0.00005510918,0.00008285438,0.0001043287],"domain_scores_gemma":[0.9987649,0.0002546216,0.0004301202,0.0001623696,0.0000805608,0.000307406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0008108022,0.0003038223,0.3259147,0.0001958242,0.0001348708,0.6015344,0.0003674415,0.0003598696,0.02570267,0.0009066367,0.001718242,0.04205069],"study_design_scores_gemma":[0.00002520661,0.0003257444,0.1011925,0.00001598586,0.0001053243,0.8926394,0.0001624372,0.0008898904,0.002916938,0.0004911024,0.001211224,0.00002431072],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897064,0.004288241,0.002023342,0.0006112718,0.0001162791,0.00001416458,0.0001036268,0.0002274186,0.002909222],"genre_scores_gemma":[0.9983214,0.0006616551,0.00026244,0.0001196192,0.0002667763,0.000002158028,0.0000667518,0.0000150601,0.0002841011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001745022,"threshold_uncertainty_score":0.005031884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005850590610463963,"score_gpt":0.249323805484657,"score_spread":0.243473214874193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}