{"id":"W1897393730","doi":"10.1111/ajt.12926","title":"Recurrent 2,8-Dihydroxyadenine Nephropathy: A Rare but Preventable Cause of Renal Allograft Failure","year":2014,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Public Health Service; National Institutes of Health; Rare Diseases Clinical Research Network","keywords":"Medicine; Adenine phosphoribosyltransferase; Nephropathy; Transplantation; Crystalluria; Gastroenterology; Chronic allograft nephropathy; Renal function; Urology; Kidney transplantation; Tubulopathy; Kidney disease; Internal medicine; Nephrology; Allopurinol; Pathology; Surgery; Endocrinology; Purine; Urinary system; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002381787,0.000112352,0.000213547,0.00007315532,0.00002814955,0.00001011609,0.0001902224,0.00005578574,0.00001240739],"category_scores_gemma":[0.00003996702,0.00009444966,0.0001427337,0.0001287518,0.0001567064,0.000007851866,0.00001619842,0.0001480099,0.000001081183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000863248,"about_ca_system_score_gemma":0.00006903852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002787924,"about_ca_topic_score_gemma":0.00001620269,"domain_scores_codex":[0.9989234,0.0001510891,0.0003409128,0.0001476132,0.0002619162,0.0001751227],"domain_scores_gemma":[0.9992498,0.00001880464,0.000299961,0.0001384146,0.0001773515,0.0001157189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006718786,0.00008096096,0.0007985235,0.00004869213,0.0001066074,0.00001483613,0.00008281542,0.00008245016,0.9875606,0.00001463975,0.0005915135,0.009946519],"study_design_scores_gemma":[0.0009880034,0.002488337,0.001328302,0.0001051404,0.000113753,0.0003874732,0.00008559564,0.000053381,0.9898879,0.00003350537,0.004393134,0.0001354614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716943,0.0003567772,0.02748556,0.0002573123,0.00004203699,0.00007906532,0.0000261223,0.000002704305,0.0000561421],"genre_scores_gemma":[0.9958983,0.0006789821,0.003027458,0.00008505691,0.0001419649,0.000003350024,0.00009959593,0.00001400567,0.0000512685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0244581,"threshold_uncertainty_score":0.3851545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005850590610463963,"score_gpt":0.249323805484657,"score_spread":0.243473214874193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}