{"id":"W1897802257","doi":"10.1593/neo.91872","title":"Impact of Metronomic UFT/Cyclophosphamide Chemotherapy and Antiangiogenic Drug Assessed in a New Preclinical Model of Locally Advanced Orthotopic Hepatocellular Carcinoma","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Sorafenib; Medicine; Hepatocellular carcinoma; Doxorubicin; Chemotherapy; Cyclophosphamide; Bevacizumab; Cancer research; Prodrug; Paclitaxel; Internal medicine; Oncology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002477703,0.0002889354,0.0008305196,0.0002197622,0.00002059553,0.000009033562,0.0001296238,0.0002146111,0.0001370006],"category_scores_gemma":[0.00006516582,0.0002475031,0.0004055944,0.0002846437,0.0001116506,0.0001064624,0.00003944371,0.0003090826,0.000004036144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000583102,"about_ca_system_score_gemma":0.0009757116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007895402,"about_ca_topic_score_gemma":0.0002500696,"domain_scores_codex":[0.9983358,0.00004535859,0.0006583492,0.0004139762,0.0002153858,0.0003310796],"domain_scores_gemma":[0.9988031,0.0001368691,0.0002282787,0.0004824924,0.00007883743,0.0002704227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000714955,0.0003637154,0.9000521,0.00008479235,0.0001569657,0.00003796418,0.0002924923,0.00002060348,0.08955774,0.00003175773,0.0000297097,0.008657218],"study_design_scores_gemma":[0.007405836,0.0006294951,0.8717507,0.00007533921,0.0001809638,0.00002843592,0.00001896799,0.05435577,0.06520784,0.0001210027,0.00003105061,0.0001946225],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973733,0.001061947,0.0002150408,0.0001299726,0.00006441098,0.0009032613,0.00001655397,0.00002504937,0.000210473],"genre_scores_gemma":[0.9925782,0.0001799006,0.006856586,0.00003165912,0.00004426454,0.00002014445,0.00003042367,0.00004541512,0.0002133979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05433517,"threshold_uncertainty_score":0.9999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02788122324249479,"score_gpt":0.2843794045145924,"score_spread":0.2564981812720976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}