{"id":"W1898108800","doi":"10.1093/annonc/mdu325.4","title":"Mir Profiling Identifies Cdk6 Down-Regulation As a Potential Mechanism of Acquired Cisplatin Resistance in Non-Small Cell Lung Carcinoma","year":2014,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Cisplatin; Cancer research; Carcinoma; Mechanism (biology); Acquired resistance; Small Cell Lung Carcinoma; Oncology; Internal medicine; Small-cell carcinoma; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187954,0.0001435639,0.0002540384,0.0005819926,0.0002289156,0.0005881853,0.0001467186,0.0002422564,0.001292581],"category_scores_gemma":[0.0003274341,0.0001652462,0.0001977963,0.0003152358,0.0001645977,0.0002508206,0.0001912087,0.0003049044,0.000427799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002633023,"about_ca_system_score_gemma":0.0001681226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004172784,"about_ca_topic_score_gemma":0.0006236976,"domain_scores_codex":[0.9998578,0.00001834968,0.00001612728,0.00003115955,0.0000516107,0.0000249957],"domain_scores_gemma":[0.999897,0.00002407142,0.0000268593,0.00001181005,0.00002413288,0.00001621248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005371661,0.00002487495,0.0237324,0.0000571143,0.00002397427,0.0003435993,0.00004321467,0.0001960581,0.9684916,0.0002561661,0.0001305934,0.006163252],"study_design_scores_gemma":[0.00002278959,0.000265013,0.1629713,0.000009816771,0.00008707016,0.002917851,0.0001679807,0.004888155,0.8248121,0.0003091843,0.003535917,0.00001261933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932514,0.001183763,0.002620399,0.00009716769,0.00001655048,0.00002333157,0.0005937799,0.00006826151,0.002145212],"genre_scores_gemma":[0.9973243,0.0003434822,0.001326958,0.00003564013,0.000005259647,0.00001127401,0.0002503574,0.00001324656,0.0006894902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292581,"threshold_uncertainty_score":0.004324138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152417513342974,"score_gpt":0.2841056917758501,"score_spread":0.2688639404415527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}