{"id":"W1898194260","doi":"10.1016/j.ccell.2015.09.003","title":"Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein","year":2015,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":219,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Drug Research and Development; Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"European Research Council; Stand Up To Cancer; Spar Nord Fonden; Novo Nordisk Fonden; Swedish Foundation for International Cooperation in Research and Higher Education; Harboefonden; National Institute of General Medical Sciences; Augustinus Fonden; Novo Nordisk UK Research Foundation; Prostate Cancer Canada; American Association for Cancer Research; St. Baldrick's Foundation; Kræftens Bekæmpelse; Innovationsfonden; U.S. Department of Defense; National Cancer Institute; Entertainment Industry Foundation","keywords":"Plasmodium falciparum; Biology; In vivo; Diphtheria toxin; Cancer cell; Glycosaminoglycan; Metastasis; Recombinant DNA; Cancer research; Chondroitin sulfate; Chondroitin; CD44; Cancer; In vitro; Cell biology; Malaria; Immunology; Biochemistry; Toxin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000812963,0.0001505691,0.0001170825,0.00005862944,0.000118818,0.0001787005,0.0001284936,0.0001783818,0.0007351706],"category_scores_gemma":[0.0000490686,0.00007151893,0.0001177255,0.0000653199,0.00011654,0.00008442244,0.0001396397,0.000357832,0.0001815951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003446941,"about_ca_system_score_gemma":0.000153729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005443,"about_ca_topic_score_gemma":0.001273348,"domain_scores_codex":[0.999965,0.000006561804,0.000001002586,0.000005253034,0.000008410335,0.00001379328],"domain_scores_gemma":[0.9999881,0.000002199683,0.000002640057,0.00000157129,0.000001567846,0.000003953976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001062925,0.00003318056,0.0001504837,0.00002670762,0.000007822153,0.0000522893,0.00001573274,0.0002349501,0.9950247,0.0006072995,0.0002775606,0.00346301],"study_design_scores_gemma":[0.00003782403,0.0006331152,0.002544239,0.000005169071,0.00003148893,0.00042197,0.00002961925,0.004568183,0.9809741,0.0001508905,0.01059897,0.000004410513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991426,0.001321723,0.004601494,0.0003166245,0.00002856766,0.00004357535,0.0001273847,0.00006326292,0.002071371],"genre_scores_gemma":[0.9939077,0.0007206767,0.003307791,0.00006157285,0.000005949397,0.00001511115,0.0001271278,0.000008175554,0.001845821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005443,"threshold_uncertainty_score":0.002500951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299800296603988,"score_gpt":0.2621970097877073,"score_spread":0.2391990068216674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}