{"id":"W1898194260","doi":"10.1016/j.ccell.2015.09.003","title":"Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein","year":2015,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":219,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Drug Research and Development; Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"European Research Council; Stand Up To Cancer; Spar Nord Fonden; Novo Nordisk Fonden; Swedish Foundation for International Cooperation in Research and Higher Education; Harboefonden; National Institute of General Medical Sciences; Augustinus Fonden; Novo Nordisk UK Research Foundation; Prostate Cancer Canada; American Association for Cancer Research; St. Baldrick's Foundation; Kræftens Bekæmpelse; Innovationsfonden; U.S. Department of Defense; National Cancer Institute; Entertainment Industry Foundation","keywords":"Plasmodium falciparum; Biology; In vivo; Diphtheria toxin; Cancer cell; Glycosaminoglycan; Metastasis; Recombinant DNA; Cancer research; Chondroitin sulfate; Chondroitin; CD44; Cancer; In vitro; Cell biology; Malaria; Immunology; Biochemistry; Toxin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003624949,0.00027785,0.0003195204,0.00006652648,0.0002676096,0.00003376486,0.0003649829,0.0003049543,0.003313682],"category_scores_gemma":[0.00002697122,0.0002660805,0.00007034926,0.0001150756,0.0001127621,0.0001533035,0.0001349777,0.0003638722,0.0006891408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005301021,"about_ca_system_score_gemma":0.0003210876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004500093,"about_ca_topic_score_gemma":0.0001654688,"domain_scores_codex":[0.9982619,0.0002608862,0.000320406,0.0004275859,0.00006738795,0.0006617786],"domain_scores_gemma":[0.999315,0.00002058514,0.0001947948,0.0002913742,0.0001111727,0.00006709038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342665,0.00005435702,0.0001809368,0.0000274713,0.0000640695,0.000006905844,0.0005281246,0.000008611273,0.9526072,0.0005339148,0.04529746,0.0005566544],"study_design_scores_gemma":[0.001652705,0.0001316301,0.000009648395,0.00006293977,0.00003494069,0.000004999297,0.0005427688,0.00001955425,0.8888211,0.00006663396,0.1083319,0.0003212102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681169,0.02494861,0.0001905031,0.0003542116,0.001900012,0.0006785825,0.0001632652,0.000181293,0.003466614],"genre_scores_gemma":[0.9538808,0.0000888732,0.0001028101,0.0002378083,0.00009330762,0.000444323,0.0001842482,0.00006328242,0.04490457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06378619,"threshold_uncertainty_score":0.9999791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299800296603988,"score_gpt":0.2621970097877073,"score_spread":0.2391990068216674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}