{"id":"W1898920617","doi":"10.1016/j.celrep.2015.09.024","title":"Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; Fonds de Recherche du Québec - Santé; Ministry of Education, Culture, Sports, Science and Technology; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Endosome; Endocytic cycle; Cell biology; Integrin; Endocytosis; Ubiquitin; Ubiquitin ligase; Fibronectin; Biology; Protein tyrosine phosphatase; Chemistry; Internalization; Receptor; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035405,0.0001871546,0.00020927,0.0001484153,0.0001505512,0.0003891621,0.0001044584,0.0002548457,0.0008198259],"category_scores_gemma":[0.000189048,0.0001370676,0.0001519691,0.0001003101,0.0002037115,0.0002916955,0.0002150132,0.000169059,0.0001378903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004512287,"about_ca_system_score_gemma":0.0001739222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006026194,"about_ca_topic_score_gemma":0.0008695227,"domain_scores_codex":[0.9998248,0.00004104877,0.00001268799,0.0000255185,0.00003394738,0.00006209462],"domain_scores_gemma":[0.9999259,0.00001377345,0.00002335941,0.000005678849,0.000007755171,0.00002355628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004484279,0.00002020804,0.002129472,0.00004277339,0.00001048105,0.0001324999,0.00001869146,0.000150168,0.994062,0.0002863118,0.00004402872,0.002655076],"study_design_scores_gemma":[0.00002879728,0.0002562711,0.09755547,0.00001010614,0.00003653018,0.0007588367,0.0001134477,0.002645933,0.8968381,0.0003222119,0.001420159,0.00001412951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961157,0.002175915,0.0007877469,0.00006230149,0.000006600842,0.000005361106,0.00007790948,0.00001019744,0.0007582518],"genre_scores_gemma":[0.9989961,0.0004413674,0.0001793319,0.0000171554,0.000002644238,0.000002901293,0.00003849144,0.000001893826,0.0003201986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008198259,"threshold_uncertainty_score":0.003273845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.019219070826028,"score_gpt":0.3043171224590724,"score_spread":0.2850980516330445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}