{"id":"W1899153802","doi":"10.1016/j.jneuroim.2015.11.002","title":"Exome and regulatory element sequencing of neuromyelitis optica patients","year":2015,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Genome Canada","funders":"Evald ja Hilda Nissin Säätiö; Academy of Finland; Canada Research Chairs; Mary och Georg C. Ehrnrooths Stiftelse; Ögonfonden; Helsingin ja Uudenmaan Sairaanhoitopiiri","keywords":"Neuromyelitis optica; Exome sequencing; Exome; Medicine; DNA sequencing; Computational biology; Genetics; Biology; Immunology; Gene; Mutation; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000153434,0.00009204124,0.0001805936,0.00009183278,0.00002349652,0.000007490498,0.0001463726,0.00007479723,0.000008454231],"category_scores_gemma":[0.0003890176,0.00008364155,0.00006267575,0.00004407998,0.0001070526,0.00001038238,0.0001208069,0.0001615876,0.000001682408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002955123,"about_ca_system_score_gemma":0.0001178912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005852793,"about_ca_topic_score_gemma":0.000001030418,"domain_scores_codex":[0.9991049,0.0001123988,0.0004003563,0.000122457,0.0001257104,0.0001342144],"domain_scores_gemma":[0.9989599,0.00001975118,0.000379622,0.0002025944,0.0003718155,0.00006629536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001774585,0.00006169462,0.006590755,0.000008535257,0.00007033343,0.00001932139,0.00007718375,0.00004798981,0.9908257,0.00006342632,0.0004789023,0.001578681],"study_design_scores_gemma":[0.004142286,0.01100682,0.684809,0.00008920604,0.00009681142,0.002356043,0.0004418007,0.0000307317,0.2372643,0.0005814847,0.05884609,0.0003353638],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982431,0.0006729627,0.0001027857,0.0001789758,0.000464444,0.0000711531,0.000004539193,0.000002198839,0.0002598744],"genre_scores_gemma":[0.9988347,0.0001680892,0.000694247,0.0001108165,0.00008522233,0.000001816924,0.000003361504,0.00001318831,0.00008858577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7535614,"threshold_uncertainty_score":0.3410803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174320382601745,"score_gpt":0.2490455572593741,"score_spread":0.2273023534333566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}