{"id":"W1900581944","doi":"10.4049/jimmunol.170.2.765","title":"Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the Vβ8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4 or -10","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Experimental autoimmune encephalomyelitis; Recombinant DNA; T-cell receptor; Vector (molecular biology); Virology; Immunology; Encephalomyelitis; Viral vector; Biology; T cell; Multiple sclerosis; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007239344,0.000279869,0.0002792801,0.00006284775,0.0005068696,0.00009442704,0.0004626275,0.0002017159,0.000278141],"category_scores_gemma":[0.0001006012,0.0001524674,0.00009057626,0.0002160569,0.0004347261,0.00002998684,0.00005646897,0.0004545649,0.000007443821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009957999,"about_ca_system_score_gemma":0.0003569031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004113989,"about_ca_topic_score_gemma":0.00001932221,"domain_scores_codex":[0.9973612,0.001162881,0.0005069068,0.0002484482,0.0002985525,0.0004219553],"domain_scores_gemma":[0.9986649,0.0000508967,0.0005397831,0.000467803,0.0002170088,0.00005965599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007636698,0.000190431,0.00001234234,0.000004149425,0.0002844847,0.000009324986,0.0007036294,0.0000360444,0.9848743,0.00000152744,0.002475432,0.003771623],"study_design_scores_gemma":[0.001810977,0.007261509,0.00009278539,0.0000571075,0.00003257059,0.00042158,0.001309781,0.00005058672,0.9725264,0.000005109763,0.01622351,0.0002080657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847857,0.01322583,0.0007413814,0.0004894809,0.0002340962,0.0004045879,0.00001884826,0.00001209076,0.00008796555],"genre_scores_gemma":[0.9975972,0.0007698818,0.0001033504,0.0001889627,0.00008862048,0.00004575821,0.00002755978,0.00005404656,0.001124612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01374808,"threshold_uncertainty_score":0.6217442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976316109381082,"score_gpt":0.2822975330151924,"score_spread":0.2625343719213816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}