{"id":"W1900581944","doi":"10.4049/jimmunol.170.2.765","title":"Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the Vβ8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4 or -10","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Experimental autoimmune encephalomyelitis; Recombinant DNA; T-cell receptor; Vector (molecular biology); Virology; Immunology; Encephalomyelitis; Viral vector; Biology; T cell; Multiple sclerosis; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000397042,0.001002279,0.0005159634,0.0004688924,0.0001585062,0.0004032758,0.0002537128,0.0005513156,0.001785946],"category_scores_gemma":[0.0001510494,0.0002553848,0.0003700255,0.0001969473,0.0004107056,0.0003042163,0.0002221529,0.001432282,0.0005886239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002035721,"about_ca_system_score_gemma":0.0003384776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002759839,"about_ca_topic_score_gemma":0.0003410292,"domain_scores_codex":[0.9996748,0.00006462921,0.00003453943,0.00005926514,0.00006493503,0.0001018547],"domain_scores_gemma":[0.9997196,0.00006011863,0.0000746014,0.00004619912,0.00002226909,0.00007723155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002494846,0.0001337559,0.00008928352,0.0000468236,0.00001081812,0.00003959768,0.00001378105,0.00003738236,0.9978687,0.0001095232,0.00003839443,0.001362515],"study_design_scores_gemma":[0.00009684142,0.002591115,0.001629669,0.00002026004,0.00003423281,0.0003780868,0.00002214317,0.0004743124,0.9925736,0.00007564463,0.002099392,0.000004710795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907958,0.001684286,0.004359819,0.0001646738,0.0001645595,0.00007661089,0.0002458412,0.0002901272,0.002218403],"genre_scores_gemma":[0.9888654,0.001634305,0.004403555,0.0001044453,0.00005076784,0.00007885094,0.0006023549,0.00005194411,0.004208437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001785946,"threshold_uncertainty_score":0.005974531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976316109381082,"score_gpt":0.2822975330151924,"score_spread":0.2625343719213816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}