{"id":"W1901056508","doi":"10.1016/j.ygyno.2015.04.034","title":"No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer","year":2015,"lang":"en","type":"review","venue":"Gynecologic Oncology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto; University Health Network; Women's College Hospital; Alberta Health Services; BC Cancer Agency; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute","funders":"Niilo Helanderin Säätiö; Medical Research and Materiel Command; National Cancer Institute; European Regional Development Fund; Seventh Framework Programme; Instituto de Salud Carlos III; Cancer Council Western Australia; Cancer Council NSW; Cancer Council Victoria; Cancer Center, University of Kansas; National Institutes of Health; Centre Léon Bérard; Institut Català de la Salut; Liepaja City Council; Gesellschaft der Freunde der Medizinischen Hochschule Hannover; Universität Ulm; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Federal Agency for Science and Innovation; Uppsala Universitet; Clalit Health Services; Institute of Cancer Research; Hospices Civils de Lyon; Legal Services Corporation; Syöpäjärjestöt; Radboud Universitair Medisch Centrum; National Health and Medical Research Council; Deutsche Krebshilfe; Royal Marsden NHS Foundation Trust; Sahlgrenska Universitetssjukhuset; Oulun Yliopisto; National Institute for Health and Care Research; Jewish General Hospital; Canadian Institutes of Health Research; European Commission; Lietuvos Mokslo Taryba; Kuopion Yliopistollinen Sairaala; Istituto Toscano Tumori; Roswell Park Cancer Institute; Israel Cancer Association; Linköpings Universitet; Sigrid Juséliuksen Säätiö; Unicancer; General Secretariat for Research and Technology; Norges Forskningsråd; Lunds Universitet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; California Breast Cancer Research Program; McGill University; Generalitat de Catalunya; Cancer Council South Australia; Istituto Oncologico Veneto; Memorial Sloan-Kettering Cancer Center; Institut National Du Cancer; Cancer Council Queensland; Oak Foundation; Leids Universitair Medisch Centrum; Fundacja na rzecz Nauki Polskiej; Breakthrough Breast Cancer; Fundación Científica Asociación Española Contra el Cáncer; Vrije Universiteit Amsterdam; Ohio State University; Canadian Breast Cancer Research Alliance; Universiteit Leiden; Celma Mastry Ovarian Cancer Foundation; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Cancerfonden; Wellcome; Friedrich-Alexander-Universität Erlangen-Nürnberg; Robert Bosch Stiftung; Hungarian Scientific Research Fund; Cancer Association of South Africa; Cancer Institute NSW; Wellcome Trust; Agence Nationale de la Recherche; American Cancer Society; Radboud Universiteit; Cancer Australia; State Education Development Agency Republic of Latvia; Helsingin ja Uudenmaan Sairaanhoitopiiri; Department of Defence, Australian Government; Academy of Finland; King's College London; Cancer Research UK; Vlaamse regering; Fundación Mutua Madrileña; Hamburger Krebsgesellschaft; Center for Molecular Medicine Cologne, University of Cologne; Lon V. Smith Foundation; Rutgers Cancer Institute of New Jersey; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Bundesministerium für Bildung und Forschung; Francis Crick Institute; Génome Québec; Cancer Care Ontario; Deutsches Krebsforschungszentrum; Fred C. and Katherine B. Andersen Foundation; Umeå Universitet; Helsingin Yliopisto; Ljósmæðrafélag Íslands; Ligue Contre le Cancer; Kansas Bioscience Authority; Cancer Council Tasmania; Itä-Suomen Yliopisto; Fox Chase Cancer Center; KWF Kankerbestrijding; Agency for Science, Technology and Research; University of Chicago; U.S. Department of Health and Human Services; Creighton University; Ministerstwo Edukacji i Nauki; Nordic Cancer Union; Breast Cancer Research Foundation; National Breast Cancer Foundation; European Social Fund; Medical Research Council; Mayo Foundation for Medical Education and Research; University of Melbourne; California Department of Public Health; Kræftens Bekæmpelse; National Institute on Handicapped Research; Susan G. Komen for the Cure; Associazione Italiana per la Ricerca sul Cancro; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; Fondation de France; Universitair Medisch Centrum Groningen; Minnesota Ovarian Cancer Alliance; Susan G. Komen; Ministerio de Economía y Competitividad; Erasmus Medisch Centrum; Beth Israel Deaconess Medical Center; Fonds Wetenschappelijk Onderzoek; U.S. Army; Landspítali Háskólasjúkrahús; Ovarian Cancer Research Fund","keywords":"Medicine; Ovarian cancer; Oncology; KRAS; Internal medicine; Breast cancer; Gynecology; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008178525,0.00044427,0.001524484,0.0006000475,0.0001365199,0.0008083112,0.0006429986,0.0008706744,0.003411268],"category_scores_gemma":[0.001739378,0.0001654182,0.0007701523,0.0005921069,0.0004578887,0.0005676673,0.0003793278,0.001193748,0.0008008838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003249869,"about_ca_system_score_gemma":0.0008496981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007055334,"about_ca_topic_score_gemma":0.002180264,"domain_scores_codex":[0.9997503,0.00005995478,0.00004198919,0.00006595957,0.00006077048,0.0000209883],"domain_scores_gemma":[0.9993201,0.0005023188,0.00005839581,0.00001708745,0.00007525923,0.00002684994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003578299,0.00003206893,0.00205262,0.007876148,0.000386713,0.0003757702,0.00003434577,0.0002902523,0.00139784,0.002294905,0.02349131,0.9614101],"study_design_scores_gemma":[0.0003564851,0.0004851499,0.008282021,0.009288355,0.002550196,0.00408916,0.0001317902,0.000548295,0.00217119,0.007310387,0.964715,0.0000720063],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006790573,0.9966075,0.0002004248,0.0007815493,0.0003135553,0.000004930401,0.00006065361,0.000008264067,0.00134412],"genre_scores_gemma":[0.0162484,0.9784531,0.0007193958,0.002240857,0.0008352148,0.00001574203,0.000209923,0.000009708103,0.001267604],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003411268,"threshold_uncertainty_score":0.01141179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1134695890063845,"score_gpt":0.4450241479230762,"score_spread":0.3315545589166916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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