{"id":"W1901056508","doi":"10.1016/j.ygyno.2015.04.034","title":"No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer","year":2015,"lang":"en","type":"review","venue":"Gynecologic Oncology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto; University Health Network; Women's College Hospital; Alberta Health Services; BC Cancer Agency; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute","funders":"Niilo Helanderin Säätiö; Medical Research and Materiel Command; National Cancer Institute; European Regional Development Fund; Seventh Framework Programme; Instituto de Salud Carlos III; Cancer Council Western Australia; Cancer Council NSW; Cancer Council Victoria; Cancer Center, University of Kansas; National Institutes of Health; Centre Léon Bérard; Institut Català de la Salut; Liepaja City Council; Gesellschaft der Freunde der Medizinischen Hochschule Hannover; Universität Ulm; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Federal Agency for Science and Innovation; Uppsala Universitet; Clalit Health Services; Institute of Cancer Research; Hospices Civils de Lyon; Legal Services Corporation; Syöpäjärjestöt; Radboud Universitair Medisch Centrum; National Health and Medical Research Council; Deutsche Krebshilfe; Royal Marsden NHS Foundation Trust; Sahlgrenska Universitetssjukhuset; Oulun Yliopisto; National Institute for Health and Care Research; Jewish General Hospital; Canadian Institutes of Health Research; European Commission; Lietuvos Mokslo Taryba; Kuopion Yliopistollinen Sairaala; Istituto Toscano Tumori; Roswell Park Cancer Institute; Israel Cancer Association; Linköpings Universitet; Sigrid Juséliuksen Säätiö; Unicancer; General Secretariat for Research and Technology; Norges Forskningsråd; Lunds Universitet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; California Breast Cancer Research Program; McGill University; Generalitat de Catalunya; Cancer Council South Australia; Istituto Oncologico Veneto; Memorial Sloan-Kettering Cancer Center; Institut National Du Cancer; Cancer Council Queensland; Oak Foundation; Leids Universitair Medisch Centrum; Fundacja na rzecz Nauki Polskiej; Breakthrough Breast Cancer; Fundación Científica Asociación Española Contra el Cáncer; Vrije Universiteit Amsterdam; Ohio State University; Canadian Breast Cancer Research Alliance; Universiteit Leiden; Celma Mastry Ovarian Cancer Foundation; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Cancerfonden; Wellcome; Friedrich-Alexander-Universität Erlangen-Nürnberg; Robert Bosch Stiftung; Hungarian Scientific Research Fund; Cancer Association of South Africa; Cancer Institute NSW; Wellcome Trust; Agence Nationale de la Recherche; American Cancer Society; Radboud Universiteit; Cancer Australia; State Education Development Agency Republic of Latvia; Helsingin ja Uudenmaan Sairaanhoitopiiri; Department of Defence, Australian Government; Academy of Finland; King's College London; Cancer Research UK; Vlaamse regering; Fundación Mutua Madrileña; Hamburger Krebsgesellschaft; Center for Molecular Medicine Cologne, University of Cologne; Lon V. Smith Foundation; Rutgers Cancer Institute of New Jersey; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Bundesministerium für Bildung und Forschung; Francis Crick Institute; Génome Québec; Cancer Care Ontario; Deutsches Krebsforschungszentrum; Fred C. and Katherine B. Andersen Foundation; Umeå Universitet; Helsingin Yliopisto; Ljósmæðrafélag Íslands; Ligue Contre le Cancer; Kansas Bioscience Authority; Cancer Council Tasmania; Itä-Suomen Yliopisto; Fox Chase Cancer Center; KWF Kankerbestrijding; Agency for Science, Technology and Research; University of Chicago; U.S. Department of Health and Human Services; Creighton University; Ministerstwo Edukacji i Nauki; Nordic Cancer Union; Breast Cancer Research Foundation; National Breast Cancer Foundation; European Social Fund; Medical Research Council; Mayo Foundation for Medical Education and Research; University of Melbourne; California Department of Public Health; Kræftens Bekæmpelse; National Institute on Handicapped Research; Susan G. Komen for the Cure; Associazione Italiana per la Ricerca sul Cancro; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; Fondation de France; Universitair Medisch Centrum Groningen; Minnesota Ovarian Cancer Alliance; Susan G. Komen; Ministerio de Economía y Competitividad; Erasmus Medisch Centrum; Beth Israel Deaconess Medical Center; Fonds Wetenschappelijk Onderzoek; U.S. Army; Landspítali Háskólasjúkrahús; Ovarian Cancer Research Fund","keywords":"Medicine; Ovarian cancer; Oncology; KRAS; Internal medicine; Breast cancer; Gynecology; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00209313,0.0005073251,0.002525251,0.0000861314,0.00006872442,0.00001146248,0.0006614387,0.002401586,0.001103163],"category_scores_gemma":[0.001706765,0.0003677521,0.0008646157,0.0001708406,0.0003849794,0.000004293948,0.0003878268,0.0003152875,0.00005285111],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002353366,"about_ca_system_score_gemma":0.006147192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002953881,"about_ca_topic_score_gemma":0.0001586243,"domain_scores_codex":[0.9957311,0.001004968,0.001565232,0.001021814,0.0001534537,0.0005234064],"domain_scores_gemma":[0.9962161,0.0005584977,0.001368574,0.0008771064,0.000715375,0.0002643209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006402847,0.0008456733,0.00009851314,0.004052473,0.0007400451,0.00002631601,0.000003812258,0.00000148223,0.00004061392,0.00006478772,0.05430758,0.9391784],"study_design_scores_gemma":[0.001165305,0.001437463,0.0005895309,0.0003074018,0.001248853,0.0001481793,0.000004911339,0.00002568464,0.000005491725,0.00009267731,0.994583,0.0003915226],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001515834,0.9880555,0.0004515277,0.0001025542,0.002859542,0.003061539,0.00276523,0.00003318733,0.002519355],"genre_scores_gemma":[0.0002290112,0.9915667,0.002624552,0.0001892047,0.001645252,0.0009073566,0.001361882,0.00007001879,0.001406006],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9402754,"threshold_uncertainty_score":0.9998775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1134695890063845,"score_gpt":0.4450241479230762,"score_spread":0.3315545589166916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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