{"id":"W1901381303","doi":"10.1111/j.1464-410x.2010.09648.x","title":"Targeted prostate cancer screening in men with mutations in <i>BRCA1</i> and <i>BRCA2</i> detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study","year":2010,"lang":"en","type":"article","venue":"British Journal of Urology","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; National Institute for Health and Care Research; Cancer Research UK; Royal Marsden NHS Foundation Trust","keywords":"Prostate cancer; Prostate; Cancer; Medicine; Oncology; BRCA2 Protein; Internal medicine; Mutation; Biology; Gene; Genetics; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01649234,0.001412527,0.001667526,0.0008966398,0.0004932842,0.001554509,0.001638759,0.001350503,0.003189562],"category_scores_gemma":[0.03046758,0.0006206908,0.004140764,0.001933573,0.000744589,0.001377145,0.001023004,0.001219641,0.0005621843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009993769,"about_ca_system_score_gemma":0.002016118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005771197,"about_ca_topic_score_gemma":0.00947972,"domain_scores_codex":[0.9889095,0.006132015,0.0008628782,0.001090419,0.002292858,0.0007122028],"domain_scores_gemma":[0.968525,0.01528156,0.005280742,0.003009928,0.005743433,0.002159373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.129425,0.0020027,0.7952653,0.004043085,0.0109997,0.00029302,0.0004944131,0.0006606653,0.00268132,0.0003639446,0.003415601,0.05035537],"study_design_scores_gemma":[0.01856665,0.03661406,0.9091509,0.001948568,0.02418487,0.00047639,0.0003570714,0.0007903593,0.00211354,0.000477467,0.005226052,0.00009401991],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9333676,0.03213969,0.003907717,0.002929139,0.0003602564,0.005601233,0.01224551,0.00009455348,0.009354157],"genre_scores_gemma":[0.9780043,0.007656856,0.002700785,0.001305283,0.0003946355,0.001476133,0.007565125,0.00004368619,0.000853198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01649234,"threshold_uncertainty_score":0.08722085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007861371815709096,"score_gpt":0.2761285712541005,"score_spread":0.2682671994383913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}