{"id":"W1901504663","doi":"10.18433/j3fp4d","title":"The Risk of Recrystallization: Changes to the Toxicity and Morphology of Pyrimethamine","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center for High Performance Computing; University of Cape Town; North-West University","keywords":"Recrystallization (geology); Solubility; Pyrimethamine; Chemistry; Dissolution; Chemical engineering; Organic chemistry; Biology; Plasmodium falciparum","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392084,0.0002201414,0.0001468747,0.0001339661,0.0001216108,0.0002849208,0.0002377169,0.0002668516,0.001253935],"category_scores_gemma":[0.0003898972,0.0001239217,0.0002591605,0.0001342925,0.0002261217,0.0002768819,0.0001607276,0.0004707336,0.0002166895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002388515,"about_ca_system_score_gemma":0.000149194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004665124,"about_ca_topic_score_gemma":0.0005984491,"domain_scores_codex":[0.9998643,0.00001326996,0.00001288784,0.00002526023,0.00006730366,0.00001686418],"domain_scores_gemma":[0.999793,0.00004292909,0.00009432793,0.00002717854,0.00002969553,0.00001300024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008628838,0.00001764946,0.001128503,0.0000717291,0.000009836455,0.0001317006,0.00001800649,0.0005120289,0.9949242,0.00008427222,0.00003279873,0.002982991],"study_design_scores_gemma":[0.000005942265,0.0002735668,0.004180248,0.00000511849,0.00001120967,0.0003930084,0.00001663947,0.001588234,0.9927286,0.00003670017,0.0007559035,0.000004854549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994688,0.000802811,0.003456521,0.00005746532,0.000007231737,0.00002217494,0.0001659139,0.00006585636,0.0007341268],"genre_scores_gemma":[0.9962727,0.0003630961,0.00250106,0.00001526077,0.000002866211,0.00001077178,0.0001812498,0.00002176934,0.0006312461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253935,"threshold_uncertainty_score":0.004194796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1475437207083925,"score_gpt":0.455957143292085,"score_spread":0.3084134225836925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}