{"id":"W1901625012","doi":"10.4049/jimmunol.0801772","title":"Suppression of NF-κB by Cyclosporin A and Tacrolimus (FK506) via Induction of the C/EBP Family: Implication for Unfolded Protein Response","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, New York University; Nagoya City University; University of Miyazaki; York University; Astellas Pharma; Centre National de la Recherche Scientifique; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Unfolded protein response; Tunicamycin; Calcineurin; Thapsigargin; Chemistry; Cytokine; Tumor necrosis factor alpha; Pharmacology; Internal medicine; Endocrinology; Biology; Immunology; Cell biology; Medicine; Transplantation; Endoplasmic reticulum","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257602,0.0003410721,0.0002075583,0.0001498807,0.0001556619,0.0002582848,0.0001378455,0.0002288403,0.0007996872],"category_scores_gemma":[0.00008693626,0.00006811844,0.0002194741,0.0001387516,0.0002223684,0.0001907983,0.0001185308,0.0003717684,0.0002343766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539988,"about_ca_system_score_gemma":0.0001689051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002522899,"about_ca_topic_score_gemma":0.0003653629,"domain_scores_codex":[0.999909,0.00001634417,0.00001384486,0.00001617174,0.00001971342,0.00002498885],"domain_scores_gemma":[0.9999088,0.000008812182,0.00003638565,0.00001006152,0.0000126906,0.00002335879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001613726,0.00002594513,0.0001170736,0.00007004853,0.000005475454,0.00006670958,0.000008818241,0.00002918815,0.9974988,0.00007697427,0.00002527706,0.00191433],"study_design_scores_gemma":[0.00004380416,0.0004095775,0.008712694,0.0000182552,0.0000370542,0.0008111444,0.00004227862,0.0007677484,0.9850507,0.0001372398,0.003962473,0.00000700531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760265,0.01537629,0.005350175,0.0003349817,0.0001161014,0.00002756573,0.0002425303,0.0001195018,0.002406344],"genre_scores_gemma":[0.9914882,0.005132664,0.001841931,0.00007046719,0.00004037578,0.00002810792,0.0001829206,0.00001069198,0.001204544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007996872,"threshold_uncertainty_score":0.002675235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004920079524197834,"score_gpt":0.2377203664034593,"score_spread":0.2328002868792615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}