{"id":"W1901786564","doi":"10.1111/febs.13411","title":"Simultaneous depletion of Atm and Mdl rebalances cytosolic Fe‐S cluster assembly but not heme import into the mitochondrion of <i>Trypanosoma brucei</i>","year":2015,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"Seventh Framework Programme","keywords":"Trypanosoma brucei; Mitochondrion; Heme; Cytosol; Biochemistry; Biology; ATP-binding cassette transporter; Aconitase; Cell biology; Saccharomyces cerevisiae; Alternative oxidase; Iron–sulfur cluster; Downregulation and upregulation; Mutant; Cofactor; Transporter; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002129747,0.0001373555,0.0001956928,0.00003625635,0.00007838947,0.00003316289,0.0002609587,0.0001760679,0.000003632102],"category_scores_gemma":[0.0003730327,0.00009301828,0.0001096677,0.00008473177,0.0001949146,0.00000723102,0.000190364,0.000232721,0.000001918494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001556949,"about_ca_system_score_gemma":0.0001461652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006488692,"about_ca_topic_score_gemma":0.00003145401,"domain_scores_codex":[0.9987124,0.0001178197,0.0003481758,0.0002095302,0.0003799671,0.0002321189],"domain_scores_gemma":[0.9990016,0.00003533341,0.0002196557,0.0002474864,0.0003189911,0.0001768935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004272838,0.00005115387,0.00138044,0.00002308709,0.00004517892,0.00001418714,0.0001147174,0.00003290371,0.9939961,0.000007008245,0.001820072,0.002087813],"study_design_scores_gemma":[0.0009096285,0.0005933734,0.0009170952,0.00003736296,0.00002163707,0.0005412188,0.0001311958,0.0002166356,0.9860272,0.0001480757,0.01033126,0.0001253514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953993,0.00235494,0.000926361,0.0008224567,0.000125499,0.0001357776,0.000008167995,0.000003393107,0.0002241302],"genre_scores_gemma":[0.9977674,0.0006367742,0.0006682784,0.0003114677,0.0003153791,0.000004320498,0.000019839,0.0000163994,0.0002600636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008511187,"threshold_uncertainty_score":0.3793176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371817608815789,"score_gpt":0.2735507697256569,"score_spread":0.259832593637499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}