{"id":"W1901786564","doi":"10.1111/febs.13411","title":"Simultaneous depletion of Atm and Mdl rebalances cytosolic Fe‐S cluster assembly but not heme import into the mitochondrion of <i>Trypanosoma brucei</i>","year":2015,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"Seventh Framework Programme","keywords":"Trypanosoma brucei; Mitochondrion; Heme; Cytosol; Biochemistry; Biology; ATP-binding cassette transporter; Aconitase; Cell biology; Saccharomyces cerevisiae; Alternative oxidase; Iron–sulfur cluster; Downregulation and upregulation; Mutant; Cofactor; Transporter; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009102373,0.0003040353,0.0003075507,0.0001459172,0.0001538626,0.0003337821,0.0002842815,0.0002377635,0.0009019515],"category_scores_gemma":[0.000101727,0.0001589894,0.0001622682,0.0001359318,0.000173087,0.000136585,0.0002129139,0.0004456823,0.0003626943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004199042,"about_ca_system_score_gemma":0.0002068313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001564104,"about_ca_topic_score_gemma":0.002186905,"domain_scores_codex":[0.9998672,0.00001416837,0.00001762781,0.00003609969,0.0000315709,0.00003327362],"domain_scores_gemma":[0.9999021,0.00001611061,0.00002355594,0.00001153923,0.00001139797,0.00003520358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005655354,0.000005571636,0.00008836905,0.00001550324,0.000001835285,0.00002220451,0.000006428381,0.00001047564,0.9995523,0.00002425014,0.00002443532,0.0001919529],"study_design_scores_gemma":[0.00001536819,0.0001016579,0.004712125,0.000005069259,0.00001415946,0.0001214126,0.00003253352,0.0007440542,0.9921415,0.00002366894,0.002084061,0.000004314834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965913,0.0008233353,0.0008268498,0.0001429416,0.00003025584,0.00001163719,0.0005014113,0.0000945538,0.0009777903],"genre_scores_gemma":[0.9950737,0.0003748053,0.0009174205,0.0001026323,0.0000123128,0.00003191159,0.001069854,0.0000442438,0.002373079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564104,"threshold_uncertainty_score":0.003109992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371817608815789,"score_gpt":0.2735507697256569,"score_spread":0.259832593637499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}