{"id":"W1901948746","doi":"10.1016/j.jalz.2015.05.009","title":"Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans","year":2015,"lang":"en","type":"review","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":321,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; Servier; Eisai; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Science Foundation","keywords":"Genome-wide association study; Computational biology; Exome sequencing; Biology; Alzheimer's Disease Neuroimaging Initiative; Genetic association; Epigenomics; Exome; Disease; Phenotype; Genetics; Medicine; Neuroscience; Single-nucleotide polymorphism; Genotype; Cognitive impairment; Cognition; DNA methylation; Gene; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07399821,0.001244168,0.001906399,0.00368529,0.0008501848,0.004159081,0.002035338,0.002441336,0.002906576],"category_scores_gemma":[0.04242037,0.0008247241,0.001362458,0.003841589,0.002722879,0.005843614,0.002941127,0.005518713,0.001352192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002206531,"about_ca_system_score_gemma":0.008031022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00532197,"about_ca_topic_score_gemma":0.006770598,"domain_scores_codex":[0.9904021,0.005192806,0.001359213,0.001059562,0.001541993,0.0004443023],"domain_scores_gemma":[0.9252365,0.0384689,0.003532179,0.003677505,0.02481815,0.004266806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001668448,0.0001259887,0.02305982,0.009123939,0.0008434318,0.0004139936,0.001017663,0.001206822,0.002714085,0.02948669,0.1823356,0.7480036],"study_design_scores_gemma":[0.0004009547,0.001203147,0.04508022,0.03387621,0.001802973,0.001377285,0.001232869,0.001937304,0.001687535,0.1329867,0.7779225,0.0004923776],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007657439,0.6500722,0.04071301,0.274478,0.01120469,0.0008168974,0.00508954,0.000729742,0.009238594],"genre_scores_gemma":[0.04593408,0.6733337,0.1521121,0.07920837,0.03366668,0.002588286,0.009041841,0.0005435981,0.003571212],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.07399821,"threshold_uncertainty_score":0.3913446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2611317494780013,"score_gpt":0.4315213269182164,"score_spread":0.1703895774402151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}