{"id":"W1902417787","doi":"10.1111/j.1365-2249.2011.04367.x","title":"Immunoglobulin subclass determines ability of immunoglobulin (Ig)G to capture and activate neutrophils presented as normal human IgG or disease-associated anti-neutrophil cytoplasm antibody (ANCA)-IgG","year":2011,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"CD16; Subclass; Immunology; Immunoglobulin G; Fc receptor; CD64; Antibody; Receptor; Fragment crystallizable region; Granulocyte; Antigen; Biology; Chemistry; Biochemistry; CD8; CD3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006780701,0.000703704,0.00183711,0.0003188734,0.0002978802,0.00004393384,0.0007876523,0.0007151334,0.001177881],"category_scores_gemma":[0.00132971,0.0005903196,0.0005795876,0.0005783145,0.002080922,0.0002381105,0.001433986,0.001203981,0.0001712634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002525029,"about_ca_system_score_gemma":0.0003687163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009406696,"about_ca_topic_score_gemma":0.0000190804,"domain_scores_codex":[0.9938322,0.0009421897,0.002084279,0.001370344,0.0006196282,0.001151354],"domain_scores_gemma":[0.9960929,0.0005436503,0.0005609331,0.001586317,0.0004475586,0.0007686684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01477046,0.004661772,0.1172957,0.00007773857,0.0005725552,0.0007377336,0.0004947109,7.629784e-7,0.8608215,0.00006712044,0.0001392695,0.00036066],"study_design_scores_gemma":[0.005914295,0.005205441,0.6262284,0.0001632009,0.0001335848,0.0001131091,0.000466415,0.00001728177,0.3608693,0.00004995994,0.0004287176,0.0004103312],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939867,0.002251535,0.000007981953,0.0006234214,0.0005063619,0.001807572,0.00008717144,0.00015571,0.0005735088],"genre_scores_gemma":[0.9973947,0.0004803967,0.0003405581,0.0004367208,0.0001163906,0.0001177033,0.0002099572,0.0001138523,0.0007897687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5089327,"threshold_uncertainty_score":0.9997352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06938947294751067,"score_gpt":0.4092714116944523,"score_spread":0.3398819387469416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}