{"id":"W1902417787","doi":"10.1111/j.1365-2249.2011.04367.x","title":"Immunoglobulin subclass determines ability of immunoglobulin (Ig)G to capture and activate neutrophils presented as normal human IgG or disease-associated anti-neutrophil cytoplasm antibody (ANCA)-IgG","year":2011,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"CD16; Subclass; Immunology; Immunoglobulin G; Fc receptor; CD64; Antibody; Receptor; Fragment crystallizable region; Granulocyte; Antigen; Biology; Chemistry; Biochemistry; CD8; CD3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003593068,0.0002572992,0.0002155553,0.0002002432,0.00007447352,0.0003647613,0.0001989675,0.0003931228,0.001676754],"category_scores_gemma":[0.0003764455,0.0001107616,0.000235659,0.000168278,0.0001500227,0.0001843058,0.0001666356,0.000336904,0.0003880977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002267148,"about_ca_system_score_gemma":0.0001551383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001071772,"about_ca_topic_score_gemma":0.0009223748,"domain_scores_codex":[0.9996663,0.00005960718,0.00002621774,0.00005395546,0.00005875837,0.0001351268],"domain_scores_gemma":[0.9997998,0.00007938779,0.00002513523,0.00002415469,0.00003238824,0.00003915555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072202,0.00003409126,0.00112809,0.00002527016,0.000006058555,0.00003352622,0.00001624259,0.00003469211,0.9970318,0.00004085571,0.00002328432,0.001518806],"study_design_scores_gemma":[0.00001949561,0.001108276,0.04822703,0.00001774373,0.00005692432,0.0004637013,0.00007180799,0.001015775,0.9468989,0.00009568689,0.002016231,0.000008318452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966449,0.0008528084,0.000985454,0.00003144983,0.00001352777,0.00002886709,0.0001095293,0.00001500326,0.001318504],"genre_scores_gemma":[0.9968578,0.0006184039,0.0006710666,0.00005473864,0.00001177815,0.00002720261,0.000267295,0.00001219404,0.001479555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676754,"threshold_uncertainty_score":0.005609334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06938947294751067,"score_gpt":0.4092714116944523,"score_spread":0.3398819387469416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}