{"id":"W190250652","doi":"10.2174/1568026054367601","title":"Proteases and Protease-Activated Receptors (PARs): Novel Signals for Pain","year":2005,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Proteases; Neuroscience; Nociception; Protease; Receptor; Protease-activated receptor; Central nervous system; Biology; Enzyme; Biochemistry; Immunology; Thrombin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004553411,0.0007367065,0.0009302629,0.001322628,0.000244963,0.0009746663,0.0004814982,0.001236686,0.002547582],"category_scores_gemma":[0.0003128719,0.0002060212,0.0002563613,0.001316068,0.0005362084,0.001554167,0.000405282,0.001174658,0.002702538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003708933,"about_ca_system_score_gemma":0.0004319934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002841401,"about_ca_topic_score_gemma":0.0004794462,"domain_scores_codex":[0.9998431,0.00002884253,0.00001943148,0.0000246336,0.0000653465,0.00001864492],"domain_scores_gemma":[0.9998568,0.00005453495,0.00002759333,0.000004534105,0.00003573258,0.0000206273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001724043,0.0001036191,0.0003031268,0.006415401,0.00005916593,0.0007438951,0.0001116481,0.0002640527,0.0148408,0.005617486,0.01555603,0.9558124],"study_design_scores_gemma":[0.00006237313,0.0003257464,0.001847014,0.001134458,0.00008253882,0.005306914,0.0001895675,0.0001561167,0.005919873,0.005044549,0.9798982,0.00003254115],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003542498,0.9978689,0.0003132532,0.0003105141,0.0001689389,0.000003384072,0.00000685037,0.000008554369,0.0009654337],"genre_scores_gemma":[0.001945168,0.9959607,0.000379394,0.0001959615,0.0003317842,0.000005482857,0.00001487372,0.00000114327,0.001165531],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002547582,"threshold_uncertainty_score":0.00852257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1332530794711318,"score_gpt":0.3932286200051027,"score_spread":0.2599755405339709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}