{"id":"W1902558048","doi":"10.1111/j.1747-0285.2011.01204.x","title":"Synthesis and Biological Evaluation of Biotinyl Hydrazone Derivatives of Muramyl Peptides","year":2011,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation","keywords":"Muramyl dipeptide; Peptidoglycan; Biochemistry; NOD2; Biology; Antimicrobial peptides; Innate immune system; Biotinylation; Chemistry; Peptide; Receptor; In vitro; Cell wall","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000292656,0.0004029743,0.00024837,0.0001194153,0.0001421419,0.0001682732,0.0002380126,0.0003829835,0.0008029018],"category_scores_gemma":[0.0003286278,0.0001301247,0.0001753408,0.0001550453,0.0002168149,0.0002153431,0.0001899413,0.0003501534,0.0002727157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003398259,"about_ca_system_score_gemma":0.000164869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006357027,"about_ca_topic_score_gemma":0.0006884194,"domain_scores_codex":[0.9998305,0.00005367981,0.00001544131,0.00002623248,0.00004235781,0.00003178231],"domain_scores_gemma":[0.9997955,0.00004776195,0.0000478415,0.00002363606,0.00004136133,0.00004394514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000574847,0.00002152907,0.00003052075,0.00004752551,0.000002974985,0.00004540052,0.00001674332,0.0001455662,0.9989074,0.00006468192,0.00001061871,0.0006494691],"study_design_scores_gemma":[0.00001075639,0.0002935002,0.0002432211,0.000002647442,0.000004945441,0.00007193643,0.000009667681,0.0002748667,0.9981844,0.00001326948,0.0008878029,0.000002941146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902181,0.001685005,0.006162886,0.0001051841,0.00002602343,0.0000907017,0.0002333979,0.00003704743,0.001441617],"genre_scores_gemma":[0.9895382,0.001401158,0.006845582,0.00002948201,0.0000094856,0.00003745754,0.0003278167,0.00001781196,0.0017931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008029018,"threshold_uncertainty_score":0.002685964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0700642864673813,"score_gpt":0.2586688000152391,"score_spread":0.1886045135478578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}