{"id":"W1902823178","doi":"10.1042/bj3640165","title":"Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate","year":2002,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Space Agency","keywords":"Dehydroepiandrosterone; Active site; Substrate (aquarium); Chemistry; Stereochemistry; Oxidoreductase; Enzyme; Binding site; Cofactor; Histidine; Hydrogen bond; Biochemistry; Biology; Androgen; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000323686,0.0004915719,0.0009643133,0.0002405761,0.0006441041,0.001245592,0.00111547,0.0006642254,0.003190382],"category_scores_gemma":[0.0008239811,0.0003675503,0.0002879628,0.0006596489,0.000292497,0.0003581811,0.0002488614,0.001530228,0.0005991988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001893852,"about_ca_system_score_gemma":0.001047008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01180758,"about_ca_topic_score_gemma":0.01283913,"domain_scores_codex":[0.9997037,0.00004138669,0.00001299286,0.00005719687,0.0001238686,0.00006091131],"domain_scores_gemma":[0.9996628,0.00009392644,0.00004301578,0.00001265879,0.00009993889,0.00008765559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01056482,0.002529925,0.03744334,0.002870775,0.001432623,0.009857016,0.003194086,0.03414902,0.738877,0.01238546,0.08632483,0.06037118],"study_design_scores_gemma":[0.004242221,0.002504293,0.2066059,0.000604791,0.001008141,0.007379871,0.003002648,0.2414619,0.3125069,0.005462435,0.214668,0.0005528045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695264,0.009684011,0.002030327,0.0015041,0.0004019966,0.00007862807,0.00336636,0.000439992,0.01296819],"genre_scores_gemma":[0.9479196,0.007595045,0.00615928,0.0007119526,0.0001443078,0.000111381,0.02571544,0.0001692465,0.01147381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01180758,"threshold_uncertainty_score":0.02347773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03261077112588156,"score_gpt":0.2624280057636896,"score_spread":0.2298172346378081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}