{"id":"W1902823178","doi":"10.1042/bj3640165","title":"Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate","year":2002,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Space Agency","keywords":"Dehydroepiandrosterone; Active site; Substrate (aquarium); Chemistry; Stereochemistry; Oxidoreductase; Enzyme; Binding site; Cofactor; Histidine; Hydrogen bond; Biochemistry; Biology; Androgen; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004926553,0.0001222514,0.0003140626,0.0000717248,0.00005365418,0.000007389712,0.00005719476,0.0000545762,0.0003341631],"category_scores_gemma":[0.00001436692,0.00007579083,0.00005888387,0.0001386374,0.0002231524,0.00003353964,0.00001259881,0.0003324332,0.000001478194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003235092,"about_ca_system_score_gemma":0.00001354486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008759502,"about_ca_topic_score_gemma":0.00001241479,"domain_scores_codex":[0.9991175,0.00001830815,0.0002734385,0.0001594202,0.0002368079,0.0001945256],"domain_scores_gemma":[0.9996137,0.000009091234,0.00005608912,0.00009899556,0.00009930847,0.000122791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000233873,0.0001810311,0.02226258,0.00004390117,0.00006883452,0.0001430219,0.0003383899,0.000001392759,0.9762201,0.00001175195,0.0003758929,0.0001191779],"study_design_scores_gemma":[0.003669887,0.0009382859,0.2302304,0.0001656225,0.0000698353,0.001794044,0.0002917614,0.00001463771,0.7624112,0.0001508548,0.0001014979,0.0001619837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980243,0.0008119424,0.000008722721,0.0005481029,0.00001673817,0.00009306525,0.00001314872,0.000006427169,0.0004775724],"genre_scores_gemma":[0.9993941,0.00006234062,0.0002333809,0.00004100701,0.0001847361,5.605435e-7,0.000008288538,0.00001011068,0.00006549511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2138089,"threshold_uncertainty_score":0.3658852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03261077112588156,"score_gpt":0.2624280057636896,"score_spread":0.2298172346378081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}