{"id":"W1904154547","doi":"10.1158/0008-5472.can-15-0988","title":"Glioblastomas Require Integrin αvβ3/PAK4 Signaling to Escape Senescence","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Senescence; Integrin; Cancer research; Cancer; Downregulation and upregulation; Kinase; Biology; Phenotype; Signal transduction; Cell biology; Effector; Oncogene; Glioblastoma; Cell; Cell cycle; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00267229,0.0002091605,0.0003619491,0.000553534,0.0001670888,0.0001109692,0.0005623067,0.0001568685,0.001404216],"category_scores_gemma":[0.00198822,0.0001803693,0.00009493415,0.002174547,0.0002839819,0.0001579508,0.0006484876,0.001260691,0.002231032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001220314,"about_ca_system_score_gemma":0.001725312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001395768,"about_ca_topic_score_gemma":0.0002867869,"domain_scores_codex":[0.9945997,0.0003724958,0.0003399893,0.0007368501,0.00274873,0.001202263],"domain_scores_gemma":[0.9952736,0.0002048275,0.00003305394,0.000830199,0.001962921,0.001695342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001546851,0.0001323461,0.002988568,0.0002025418,0.00003689808,0.0006169078,0.00109308,0.00008996974,0.914007,0.0001747101,0.0519848,0.02712633],"study_design_scores_gemma":[0.001956732,0.001705941,0.001051976,0.0008631236,0.00001534668,0.00008699818,0.002152304,0.0004961636,0.7492544,0.0002309908,0.241827,0.0003590203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772618,0.001283807,0.000516971,0.01025078,0.0002173085,0.00120104,0.00001069069,0.0001205607,0.009136992],"genre_scores_gemma":[0.97318,0.0001253581,0.0008329482,0.0004970856,0.0006397302,0.0003228283,0.00000754907,0.00008046703,0.02431401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1898422,"threshold_uncertainty_score":0.9995086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1931303084069137,"score_gpt":0.4712506937706263,"score_spread":0.2781203853637125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}