{"id":"W1904230974","doi":"10.1158/1055-9965.epi-15-0363","title":"Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk","year":2015,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Institute of Cancer Research; Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"Medical Research and Materiel Command; National Cancer Institute; Institute of Biomedical Sciences, Academia Sinica; Universitätsklinikum Hamburg-Eppendorf; Biomedical Research Council; Medical Research Council; Canadian Institutes of Health Research; U.S. Army; National Institutes of Health; Deutschen Konsortium für Translationale Krebsforschung; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Centers for Disease Control and Prevention; Institut National Du Cancer; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Norges Forskningsråd; KWF Kankerbestrijding; Vetenskapsrådet; Karolinska Institutet; National Medical Research Council; Ministério da Ciência, Tecnologia e Inovação; Herlev Hospital; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Robert Bosch Stiftung; Kementerian Sains, Teknologi dan Inovasi; King's College London; Academy of Finland; Stockholms Läns Landsting; Singapore Eye Research Institute; National Science Council; Agence Nationale de la Recherche; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Breast Cancer Foundation; European Commission; Kuopion Yliopistollinen Sairaala; Academia Sinica; National Research Foundation; National Institute for Health and Care Research; Rheinische Friedrich-Wilhelms-Universität Bonn; Breast Cancer Research Trust; Wellcome Trust; Fondation du cancer du sein du Québec; California Breast Cancer Research Program; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; European Social Fund; Agency for Science, Technology and Research; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Cancer Council Tasmania; World Health Organization; Francis Crick Institute; Deutsche Gesetzliche Unfallversicherung; McGill University Health Centre; University of California, Irvine; David F. and Margaret T. Grohne Family Foundation; Deutsches Krebsforschungszentrum; Breast Cancer Research Foundation; McGill University; Helsingin ja Uudenmaan Sairaanhoitopiiri; Cancer Council Victoria; California Department of Public Health; Sundhed og Sygdom, Det Frie Forskningsråd; Itä-Suomen Yliopisto; Susan G. Komen for the Cure; Virginia Department of Health; Vanderbilt University; Cancer Research UK; Associazione Italiana per la Ricerca sul Cancro; Ministry of Public Health; Beckman Research Institute, City of Hope; University of Southern California; University of Cambridge; Instituto de Salud Carlos III; National Research Foundation of Korea; Ohio State University; U.S. Department of Health and Human Services; Mayo Clinic","keywords":"Locus (genetics); Breast cancer; Genetics; Biology; Medicine; Cancer; Oncology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008418671,0.0006729468,0.0006005945,0.00169214,0.0004577298,0.0006432701,0.0008731754,0.0009277695,0.005209005],"category_scores_gemma":[0.002901633,0.0002821562,0.001402745,0.001188992,0.0006909743,0.0001527519,0.001007745,0.0007780085,0.0006484947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003318308,"about_ca_system_score_gemma":0.0003288811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003606026,"about_ca_topic_score_gemma":0.003091436,"domain_scores_codex":[0.9991267,0.0001656974,0.00005241171,0.0003906639,0.0001408555,0.0001235515],"domain_scores_gemma":[0.9982039,0.0007441501,0.0005780596,0.0002076865,0.0001144097,0.0001518056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002567329,0.0002025407,0.865331,0.0001562732,0.001770906,0.002030787,0.0003128128,0.001290984,0.1033928,0.0005613205,0.000759815,0.02162348],"study_design_scores_gemma":[0.0002760934,0.0003289778,0.9881024,0.00003614043,0.0006439366,0.001581948,0.00008171485,0.001054076,0.005752608,0.0007832314,0.001333666,0.00002522513],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952774,0.0007849918,0.00238882,0.0001270398,0.00002087166,0.00003697517,0.000644238,0.00005240817,0.0006672522],"genre_scores_gemma":[0.9965053,0.0002068983,0.001560081,0.00008515727,0.00002687441,0.00005705255,0.001063882,0.00002099276,0.0004737653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005209005,"threshold_uncertainty_score":0.01742584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03070043389254382,"score_gpt":0.3120844339164638,"score_spread":0.2813840000239199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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