{"id":"W1904407543","doi":"10.1038/ng.3412","title":"Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":451,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; Public Health Ontario; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University; Royal Victoria Hospital; University of Toronto","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Advancing Translational Sciences; Wellcome Trust; National Human Genome Research Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institute on Aging; Medical Research Council; National Institute for Health and Care Research; National Cancer Institute; Cancer Research UK; National Institutes of Health; Francis Crick Institute","keywords":"Biology; Breast cancer; DNA repair; Genetics; DNA; Computational biology; Cancer research; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001797424,0.0009774384,0.0006850084,0.001072244,0.0005590013,0.0009335584,0.0005539506,0.0008370976,0.002398868],"category_scores_gemma":[0.005818944,0.0003776239,0.003102619,0.001138493,0.0003781803,0.0002302418,0.0007398373,0.001121227,0.0002411022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003786762,"about_ca_system_score_gemma":0.0003634863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004111175,"about_ca_topic_score_gemma":0.007583562,"domain_scores_codex":[0.9993419,0.0002060918,0.00004266444,0.0002572419,0.00009337444,0.00005864398],"domain_scores_gemma":[0.9951978,0.003386498,0.0004825405,0.0003996076,0.000313984,0.0002195403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009159576,0.0002574321,0.7948338,0.001515873,0.04288372,0.00297901,0.0005121753,0.0030853,0.03712408,0.001065816,0.01246237,0.09412084],"study_design_scores_gemma":[0.001373522,0.001195216,0.8887119,0.0003133225,0.05476858,0.003562906,0.0003703411,0.006130471,0.01459173,0.006259939,0.02256729,0.0001547456],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251255,0.04516291,0.01462093,0.006644379,0.0009294156,0.0001153889,0.004807905,0.0002654031,0.002328132],"genre_scores_gemma":[0.9842432,0.006892493,0.004382188,0.001462827,0.0004923792,0.00005577411,0.001061707,0.00004859483,0.001360889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004111175,"threshold_uncertainty_score":0.009505808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01935210742707185,"score_gpt":0.3130516011801563,"score_spread":0.2936994937530845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}