{"id":"W1904768480","doi":"10.1111/j.1365-2125.2010.03772.x","title":"Repaglinide‐gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism","year":2010,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"","keywords":"Repaglinide; Gemfibrozil; Glucuronidation; Chemistry; Pharmacology; Glucuronide; Microsome; Metabolite; Drug interaction; Nateglinide; Pharmacokinetics; Biochemistry; Endocrinology; Medicine; Enzyme; Metformin; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.008591873,0.0003401858,0.001200488,0.0002968013,0.0003734776,0.00005428746,0.0005211041,0.0007453563,0.03486559],"category_scores_gemma":[0.003807497,0.0003987364,0.0009049538,0.0003107768,0.0006234506,0.0005169284,0.0002442991,0.004724074,0.0001325711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000456488,"about_ca_system_score_gemma":0.0007691049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003407757,"about_ca_topic_score_gemma":0.00002575749,"domain_scores_codex":[0.9918059,0.002355895,0.004027003,0.0005286223,0.0005971483,0.0006854614],"domain_scores_gemma":[0.9902111,0.003361695,0.00369546,0.0001882646,0.001807265,0.0007361979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006110273,0.003811509,0.0009652119,0.0001074171,0.001729825,0.003331298,0.0001910509,0.0009362921,0.582544,0.00236744,0.2507088,0.1471969],"study_design_scores_gemma":[0.02128033,0.0009684001,0.004479507,0.0002000899,0.001968968,0.01062307,0.0002231941,0.004628172,0.3396718,0.01665079,0.5985164,0.0007892421],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650093,0.0007700293,0.0004744431,0.001799755,0.02853281,0.000441006,0.0009245101,0.00005483375,0.001993337],"genre_scores_gemma":[0.9811999,0.002837257,0.00172955,0.00441891,0.009195367,0.00002809997,0.0002026763,0.00005155851,0.0003367403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3478076,"threshold_uncertainty_score":0.9998465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07043696450870818,"score_gpt":0.4751353786480097,"score_spread":0.4046984141393015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}