{"id":"W1904807168","doi":"10.1002/adfm.201502778","title":"Tuning the Microenvironment: Click‐Crosslinked Hyaluronic Acid‐Based Hydrogels Provide a Platform for Studying Breast Cancer Cell Invasion","year":2015,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Self-healing hydrogels; Hyaluronic acid; Extracellular matrix; Click chemistry; Ethylene glycol; Cancer cell; Cell; Tumor microenvironment; Materials science; Matrix metalloproteinase; Cell migration; In vivo; Ligand (biochemistry); Biophysics; Cancer; Chemistry; Biochemistry; Biology; Polymer chemistry; Receptor; Organic chemistry; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132428,0.0003684967,0.0001131467,0.0001113887,0.00008818747,0.0002220345,0.0001747801,0.0002214157,0.0006861038],"category_scores_gemma":[0.00006639233,0.0001306301,0.00008630422,0.0001080038,0.000168146,0.0002846205,0.0001922456,0.0003019929,0.0001886236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002391641,"about_ca_system_score_gemma":0.000151306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002342752,"about_ca_topic_score_gemma":0.0004117982,"domain_scores_codex":[0.9999247,0.000009450257,0.000003808147,0.00002003858,0.00002532172,0.00001674594],"domain_scores_gemma":[0.9999434,0.00001186157,0.00002122462,0.000003829973,0.00000414357,0.00001549075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001061682,0.000007127585,0.00002971632,0.00001655831,9.49408e-7,0.00001291688,0.000004063888,0.00007497885,0.9992219,0.00006177215,0.00001900809,0.0005404099],"study_design_scores_gemma":[0.000005652412,0.00004964084,0.0005534283,0.000001942643,0.000003111106,0.00006097501,0.000005328273,0.000960518,0.9974011,0.00003034217,0.0009246725,0.00000332292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9777097,0.00313111,0.01561472,0.0001587884,0.00003647685,0.00003649651,0.0002639924,0.0001815774,0.002867175],"genre_scores_gemma":[0.9906874,0.001260127,0.006063141,0.00007100353,0.00001135673,0.00003265221,0.0001205583,0.00002421646,0.00172962],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0006861038,"threshold_uncertainty_score":0.002295256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0320683674095734,"score_gpt":0.2565570505553705,"score_spread":0.2244886831457971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}