{"id":"W1905042898","doi":"10.1093/hmg/ddv319","title":"A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; National Institutes of Health; Research to Prevent Blindness","keywords":"Biology; Retinitis pigmentosa; Retinal degeneration; Mutation; Mutant; Blindness; Cell biology; Visual phototransduction; Electroretinography; Retina; Night vision; Adaptation (eye); Genetics; Neuroscience; Biophysics; Gene; Medicine; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002798079,0.001485884,0.000664632,0.001426249,0.000521731,0.0004147698,0.0007325917,0.001697739,0.006471116],"category_scores_gemma":[0.0001875587,0.0003216582,0.0007292719,0.0005857038,0.0008223511,0.0005989633,0.0004493021,0.001307513,0.001482612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004241127,"about_ca_system_score_gemma":0.000281833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005962879,"about_ca_topic_score_gemma":0.0009796489,"domain_scores_codex":[0.999743,0.00003170213,0.00002825229,0.0001027453,0.00005702053,0.0000373066],"domain_scores_gemma":[0.9997546,0.00003322001,0.0000854294,0.00002998951,0.00002324768,0.00007348017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006822909,0.0002813367,0.0008357271,0.0001753952,0.00005953863,0.003342733,0.0001022098,0.0001551007,0.9847767,0.002359946,0.001411227,0.005817728],"study_design_scores_gemma":[0.0009610123,0.003862998,0.03706909,0.0003013677,0.0009181831,0.06489138,0.0003769246,0.008451293,0.7520218,0.006531055,0.1244209,0.0001940978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9271595,0.007497689,0.04297043,0.003034325,0.0007303228,0.0004607792,0.007517458,0.002797908,0.007831697],"genre_scores_gemma":[0.9307736,0.005732765,0.02613792,0.00107766,0.0001745803,0.0008796796,0.005967446,0.0005199672,0.02873654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006471116,"threshold_uncertainty_score":0.02164805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02295586343392439,"score_gpt":0.2621032371318801,"score_spread":0.2391473736979557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}