{"id":"W1905890572","doi":"10.1128/aac.01381-15","title":"Protective Effect of Ginsenosides Rg1 and Re on Lipopolysaccharide-Induced Sepsis by Competitive Binding to Toll-Like Receptor 4","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Ginseng Biological Effects and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Proinflammatory cytokine; TLR4; Lipopolysaccharide; Tumor necrosis factor alpha; Sepsis; Immune system; Interleukin; White blood cell; Receptor; Pharmacology; Toll-like receptor; Intracellular; Inflammation; Immunology; Cytokine; Chemistry; Biology; Innate immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200879,0.0005305178,0.0003989519,0.0002811883,0.0001121601,0.0001463061,0.0001419853,0.0002000655,0.0009025576],"category_scores_gemma":[0.00008563534,0.00009956792,0.0002139338,0.00008235293,0.0001919418,0.0001540669,0.0001387102,0.0003776581,0.0002108278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001205416,"about_ca_system_score_gemma":0.0001455999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002930516,"about_ca_topic_score_gemma":0.0004195125,"domain_scores_codex":[0.9999281,0.00002100846,0.000003950204,0.00001091256,0.00001015573,0.00002586653],"domain_scores_gemma":[0.9999481,0.000006651716,0.00001737332,0.00000561592,0.000004398076,0.00001776889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009680827,0.0001463494,0.0001331317,0.00006449676,0.00001443419,0.00004153515,0.000008926637,0.0001079298,0.9959644,0.00009535623,0.00003676363,0.002418546],"study_design_scores_gemma":[0.0001569611,0.003834231,0.004816819,0.00001242134,0.00004929251,0.000186596,0.00002246987,0.0006992042,0.9886076,0.00006225907,0.001543112,0.000009174825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975963,0.001085493,0.0004838567,0.00005469093,0.00001604338,0.00001389096,0.00005986087,0.00003818512,0.0006515857],"genre_scores_gemma":[0.9966857,0.001004217,0.0009230506,0.00006694493,0.00001297579,0.00001788548,0.0001459956,0.00001080161,0.001132445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009025576,"threshold_uncertainty_score":0.003019392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0147787791267024,"score_gpt":0.274253382319217,"score_spread":0.2594746031925146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}