{"id":"W1905890572","doi":"10.1128/aac.01381-15","title":"Protective Effect of Ginsenosides Rg1 and Re on Lipopolysaccharide-Induced Sepsis by Competitive Binding to Toll-Like Receptor 4","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Ginseng Biological Effects and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Proinflammatory cytokine; TLR4; Lipopolysaccharide; Tumor necrosis factor alpha; Sepsis; Immune system; Interleukin; White blood cell; Receptor; Pharmacology; Toll-like receptor; Intracellular; Inflammation; Immunology; Cytokine; Chemistry; Biology; Innate immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141119,0.0001811414,0.0002251594,0.0000316532,0.00008161507,0.0000252092,0.00008590416,0.0001294304,0.0000107944],"category_scores_gemma":[0.00003309464,0.0001347644,0.00004775473,0.0000623648,0.00007288521,0.000003663613,0.00005404238,0.00007162149,0.000005781395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001140005,"about_ca_system_score_gemma":0.00001312883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007245808,"about_ca_topic_score_gemma":0.000007323718,"domain_scores_codex":[0.9992024,0.00006951707,0.0001320211,0.0003604319,0.00006661205,0.000169049],"domain_scores_gemma":[0.9995914,0.00002773188,0.00007001153,0.0001429285,0.00004394658,0.0001240541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003391469,0.00007074171,0.001154458,0.00001799905,0.00005598789,4.086346e-7,0.0001075933,0.000001119206,0.977852,0.00002924866,0.01614861,0.004222612],"study_design_scores_gemma":[0.001048261,0.002157697,0.0006372235,0.0000480903,0.00001153209,0.000002738845,0.00005827521,0.000005120555,0.9750095,0.000009485462,0.02083362,0.000178434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975721,0.00002174912,0.00008691136,0.001407874,0.00005491941,0.0006088125,0.00008402857,0.00001188625,0.0001517089],"genre_scores_gemma":[0.9969632,0.0001277991,0.0001585012,0.002464936,0.00006256345,0.00003534699,0.00005373894,0.00001810741,0.0001158268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004685005,"threshold_uncertainty_score":0.5495535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0147787791267024,"score_gpt":0.274253382319217,"score_spread":0.2594746031925146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}