{"id":"W1905907413","doi":"10.1093/brain/awv202","title":"Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Michael J. Fox Foundation for Parkinson's Research","keywords":"Disease; Parkinson's disease; Odds ratio; Neuroimaging; Cognitive decline; LRRK2; Quartile; Biomarker; Dopamine transporter; Medicine; Biobank; Alpha-synuclein; Internal medicine; Oncology; Biology; Neuroscience; Dopamine; Dementia; Bioinformatics; Genetics; Confidence interval; Dopaminergic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001615364,0.0004123936,0.0007464824,0.0005729563,0.0003589776,0.0009840028,0.0003648773,0.0005817506,0.001089119],"category_scores_gemma":[0.00345355,0.0003391414,0.001714273,0.001120024,0.0002828176,0.0003174044,0.000359048,0.0006360812,0.0001117009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00022862,"about_ca_system_score_gemma":0.0001472001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002917286,"about_ca_topic_score_gemma":0.00363205,"domain_scores_codex":[0.9990795,0.0002946213,0.00009709356,0.0003684625,0.0001054898,0.00005480949],"domain_scores_gemma":[0.9975848,0.001066334,0.000668824,0.0003415836,0.0002420212,0.00009643394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004007865,0.0000309466,0.9677278,0.0006415346,0.01399775,0.0002955744,0.000177505,0.000293033,0.003239729,0.0001395187,0.0005785704,0.008870169],"study_design_scores_gemma":[0.00009515903,0.0002313956,0.9857376,0.00009802813,0.01058918,0.0004895168,0.00007719703,0.0005225759,0.0008362809,0.0003067368,0.001003961,0.00001242317],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754494,0.02130836,0.0008389089,0.0001640652,0.00005526799,0.00001219561,0.001259625,0.00002802927,0.0008841955],"genre_scores_gemma":[0.9976594,0.001342029,0.0002267168,0.00007534462,0.00002401142,0.000006940526,0.0004798049,0.000007363531,0.0001783296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002917286,"threshold_uncertainty_score":0.008542955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03058764727143841,"score_gpt":0.2644087106933397,"score_spread":0.2338210634219013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}