{"id":"W1906311303","doi":"10.1111/j.1365-2958.2008.06409.x","title":"Mutation in the LPS outer core biosynthesis gene, <i>galU</i>, affects LPS interaction with the RTX toxins ApxI and ApxII and cytolytic activity of <i>Actinobacillus pleuropneumoniae</i> serotype 1","year":2008,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Biological Sciences; Cegep de Saint Hyacinthe","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Actinobacillus pleuropneumoniae; Biology; Virulence; Microbiology; Mutant; Cytotoxic T cell; Secretion; Cytotoxicity; Molecular biology; Serotype; Gene; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001180239,0.000431776,0.0001582215,0.0001384408,0.00009177747,0.000246649,0.0002480188,0.0003091797,0.0007538483],"category_scores_gemma":[0.00020049,0.000155967,0.0002909043,0.00009178333,0.0002799974,0.0001146486,0.0002204739,0.000456964,0.0002279581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002669532,"about_ca_system_score_gemma":0.0001673166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009447859,"about_ca_topic_score_gemma":0.0006158958,"domain_scores_codex":[0.9997806,0.00006561975,0.00003190837,0.00003156979,0.00004963992,0.00004056576],"domain_scores_gemma":[0.9997748,0.00005794877,0.00008451437,0.00001866328,0.00001304479,0.00005110051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001377971,0.0000608412,0.0002232244,0.00001234224,0.000007308213,0.00006232631,0.00001112834,0.0001246503,0.9990026,0.00004746042,0.00001114248,0.000299307],"study_design_scores_gemma":[0.0000265413,0.0006941914,0.009245047,0.000009109322,0.00002555896,0.0003742849,0.00004956024,0.002526787,0.9862514,0.00003205849,0.0007543876,0.00001110432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990397,0.00005818516,0.0005186445,0.00002213318,0.000007923205,0.000008461012,0.00009512522,0.00001526322,0.0002343255],"genre_scores_gemma":[0.9982468,0.00007355599,0.0007551949,0.00003289596,0.000004707504,0.00001357875,0.0002596421,0.00002063658,0.0005929625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009447859,"threshold_uncertainty_score":0.002521873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01731766751518019,"score_gpt":0.239663845626598,"score_spread":0.2223461781114178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}