{"id":"W1906311303","doi":"10.1111/j.1365-2958.2008.06409.x","title":"Mutation in the LPS outer core biosynthesis gene, <i>galU</i>, affects LPS interaction with the RTX toxins ApxI and ApxII and cytolytic activity of <i>Actinobacillus pleuropneumoniae</i> serotype 1","year":2008,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Biological Sciences; Cegep de Saint Hyacinthe","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Actinobacillus pleuropneumoniae; Biology; Virulence; Microbiology; Mutant; Cytotoxic T cell; Secretion; Cytotoxicity; Molecular biology; Serotype; Gene; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003276593,0.0002351619,0.0003132782,0.0001584769,0.0002900668,0.00001998929,0.0001761974,0.0002121481,0.00003624086],"category_scores_gemma":[0.00006731529,0.000142388,0.0000711902,0.0002684772,0.0007635987,0.00008314145,0.0001170093,0.0003983278,0.00002307707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003910569,"about_ca_system_score_gemma":0.00007208865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004122425,"about_ca_topic_score_gemma":0.0003884213,"domain_scores_codex":[0.9982495,0.0007461471,0.0001911247,0.0004024496,0.00002931615,0.0003815141],"domain_scores_gemma":[0.9990437,0.0003666067,0.0001460809,0.0003413477,0.00007493505,0.00002735276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003610662,0.0001597656,0.002238595,0.00003292733,0.0001240614,0.00009589596,0.0006726857,0.00001577374,0.9947107,0.00006941308,0.0003027427,0.001216307],"study_design_scores_gemma":[0.001448515,0.0006864319,0.01088289,0.00004112696,0.0001084597,0.006878928,0.0003767443,0.00001681262,0.9750147,0.00002142074,0.004251866,0.0002721018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971339,0.0008796665,0.0003352081,0.0007472066,0.0001007045,0.0005773421,0.00007184785,0.00002124201,0.0001329573],"genre_scores_gemma":[0.9991473,0.0002081824,0.00003590914,0.0004101132,0.00001340465,0.0000393525,0.00006183515,0.00001959607,0.00006433665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01969606,"threshold_uncertainty_score":0.5806414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01731766751518019,"score_gpt":0.239663845626598,"score_spread":0.2223461781114178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}